Project description DEENESFRITPL Merging metabolomics with magnetic resonance imaging to study human biology in the whole body The EU-funded NICI project will introduce an innovative approach to studying human biology using non-invasive chemistry imaging (NICI). Developing magnetic resonance imaging (MRI) to detect recently discovered metabolic biomarkers will enable the dynamic mapping of biochemical processes in the whole body. The project will develop a new methodology using co-cultured 3D organoids as models for human organs. It will develop a platform integrating 7T MRI scanners and associated data acquisition approaches to create a 3D biochemical imaging system. The dynamic 3D chemical imaging approach and its predictive and prognostic value will be validated in the stratification strategy for patients with liver metastasis of gastrointestinal cancer. Show the project objective Hide the project objective Objective The NICI project’s ambition is to lay the foundations of a new area of research: the study of human biology using non-invasive chemistry imaging. For this, NICI aims to unite two areas of research: metabolomics and magnetic resonance imaging (MRI). Metabolomics studies body functions through the measurement of metabolites; MRI, is able to provide 3D images of the body. By advancing MRI so that it can detect metabolic biomarkers and by discovering powerful new MRI-visible biomarkers, a non-invasive technology can be developed for dynamically mapping biochemical processes in the whole human body. Vision: This new non-invasive technology for imaging biochemical processes in the human body will open a new and effective window for understanding human biology, diseases and their treatment.Breakthroughs: I. Methodology for the discovery of discriminative biomarkers and II. Technological platform for full body biochemical imaging. Novelty: Enabling a paradigm shift from morphologic imaging to biochemical understanding. Foundational: Establishing the basis for a new research area, the study of human biochemistry using non-invasive biochemical imaging.High-risk: i) The exact mechanisms of diseases are largely unknown and ii) Measuring specific metabolites is challenging. Interdisciplinary: Bringing together physicists, biologists, chemists and clinicians.The NICI project will develop a new methodology for the in vitro discovery of discriminant biomarkers using co-cultured 3D organoids as models for human organs. In addition, the project will develop a measurement platform, integrated with 7T MRI scanners and associated data acquisition approaches to adapt these MRI scanners into 3D biochemical imaging systems. NICI will validate the dynamic 3D chemical imaging approach and its predictive and prognostic value by researching a stratification strategy for patients with liver metastasis of gastrointestinal cancer. (This is one out of many possible applications.) Fields of science medical and health sciencesclinical medicineinternal medicinemedical and health sciencesclinical medicineoncologymedical and health sciencesclinical medicinepaediatricsengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imagingengineering and technologyother engineering and technologiesmicrotechnologymolecular engineering Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Topic(s) FETOPEN-01-2016-2017 - FET-Open research and innovation actions Call for proposal H2020-FETOPEN-2016-2017 See other projects for this call Sub call H2020-FETOPEN-1-2016-2017 Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSITAIR MEDISCH CENTRUM UTRECHT Net EU contribution € 558 431,25 Address Heidelberglaan 100 3584 CX Utrecht Netherlands See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (13) Sort alphabetically Sort by Net EU contribution Expand all Collapse all NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Norway Net EU contribution € 100 177,50 Address Hogskoleringen 1 7491 Trondheim See on map Region Norge Trøndelag Trøndelag Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom Net EU contribution € 392 995,00 Address Trinity lane the old schools CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands Net EU contribution € 336 093,75 Address Meibergdreef 15 1105AZ Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 IMAGO 7 FONDAZIONE DI RICERCA ONLUS Italy Net EU contribution € 379 687,50 Address Viale del tirreno 331 56128 Calambrone pisa See on map Region Centro (IT) Toscana Pisa Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. UNIVERSITA DI PISA Italy Net EU contribution € 178 656,25 Address Lungarno pacinotti 43/44 56126 Pisa See on map Region Centro (IT) Toscana Pisa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MR COILS BV Participation ended Netherlands Net EU contribution € 160 713,75 Address Shimminck 18 5301 KR Zaltbommel See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Oost-Nederland Gelderland Zuidwest-Gelderland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 GENERAL ELECTRIC DEUTSCHLAND HOLDING GMBH Participation ended Germany Net EU contribution € 0,00 Address Bleichstrasse 64-66 60313 Frankfurt am main See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 PHILIPS MEDICAL SYSTEMS NEDERLAND BV Netherlands Net EU contribution € 47 202,50 Address Veenpluis 6 5684 PC Best See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SIEMENS HEALTHCARE LIMITED United Kingdom Net EU contribution € 0,00 Address Faraday house sir william siemens square GU16 8QD Camberley See on map Region South East (England) Surrey, East and West Sussex West Surrey Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AR BENELUX B.V. Netherlands Net EU contribution € 21 000,00 Address Frankrijklaan 7 2391 PX Hazerswounde dorp See on map Region West-Nederland Zuid-Holland Oost-Zuid-Holland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. BARTHEL HF-TECHNIK GMBH Germany Net EU contribution € 162 500,00 Address Roermonder str. 321 52072 Aachen See on map Region Nordrhein-Westfalen Köln Städteregion Aachen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 TESLA DYNAMIC COILS BV Netherlands Net EU contribution € 761 352,50 Address Schimminck 12 5301KR Zaltbommel See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Oost-Nederland Gelderland Zuidwest-Gelderland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 GE HEALTHCARE GMBH Germany Net EU contribution € 48 163,75 Address Beethovenstrasse 239 42655 Solingen See on map Region Nordrhein-Westfalen Düsseldorf Solingen, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
