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Predictive Epigenetics: Fusing Theory and Experiment

Deliverables

Publications

Proximal termination generates a transcriptional state that determines the rate of establishment of Polycomb silencing

Author(s): Govind Menon, Eduardo Mateo Bonmati, Svenja Reeck, Robert Maple, Zhe Wu, Robert Ietswaart, Caroline Dean, Martin Howard
Published in: BioRxiv, 2023
Publisher: Cold Spring Harbor Laboratories (CSHL)
DOI: 10.1101/2023.07.06.547969

Comparison of the Hi-C, GAM and SPRITE methods by use of polymer models of chromatin

Author(s): Francesco Musella; Ana Pombo; Rieke Kempfer; Antonella Prisco; Andrea Esposito; Andrea M. Chiariello; Luca Fiorillo; Mattia Conte; Mario Nicodemi; Ibai Irastorza-Azcarate; Simona Bianco; Alexander Kukalev
Published in: Issue 1, 2020
Publisher: bioRxiv
DOI: 10.1101/2020.04.24.059915

GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of a distal enhancer element

Author(s): Liat Ravid Lustig, Abhishek Sampath Kumar, Till Schwämmle, Ilona Dunkel, Gemma Noviello, Raha Weigert, Guido Pacini, Rene Buschow, Afrah Ghauri, Maximilian Stoetzel, Lars Wittler, Alexander Meissner, Edda G Schulz
Published in: BioRxiv, 2022
Publisher: Cold Spring Harbor Laboratories (CSHL)
DOI: 10.1101/2022.08.02.502458

Chromatin organization drives the exploration strategy of nuclear factors

Author(s): Matteo Mazzocca, Alessia Loffreda, Emanuele Colombo, Tom Fillot, Daniela Gnani, Paola Falletta, Emanuele Monteleone, Serena Capozi, Edouard Bertrand, Gaelle Legube, Zeno Lavagnino, Carlo Tacchetti, Davide Mazza
Published in: BioRxiv, 2022
Publisher: Cold Spring Harbor Laboratories (CSHL)
DOI: 10.1101/2022.12.29.522193

Transcriptional changes are regulated by metabolic pathway dynamics but decoupled from protein levels

Author(s): Jack E. Feltham, Shidong Xi, Struan C. Murray, Meredith Wouters, Julian Urdiain-Arraiza, Raphael Heilig, Charlotte George, Anna F. Townley, Emile Roberts, Benedikt M. Kessler, Sabrina Liberatori, Philip D. Charles, Andrew Angel, Roman Fischer,
Published in: BioRxiv, 2020
Publisher: Cold Spring Harbor Laboratory (CSHL)
DOI: 10.1101/833921

Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory

Author(s): Cecilia Lovkvist, Pawel Mikulski, Svenja Reeck, Matthew Hartley, Caroline Dean, Martin Howard
Published in: eLife, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.66454

Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation

Author(s): Mattia Conte, Luca Fiorillo, Simona Bianco, Andrea M. Chiariello, Andrea Esposito, Mario Nicodemi
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17141-4

Establishment of heterochromatin in domain-size-dependent bursts

Author(s): Jan Fabio Nickels, Ashleigh Katrine Edwards, Sebastian Jespersen Charlton, Amanda Møller Mortensen, Sif Christine Lykke Hougaard, Ala Trusina, Kim Sneppen, Geneviève Thon
Published in: Proceedings of the National Academy of Sciences, Issue 118/15, 2021, Page(s) e2022887118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2022887118

CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression

Author(s): Gemma Noviello, Rutger AF Gjaltema, Edda G Schulz
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group

Cohesin and CTCF control the dynamics of chromosome folding

Author(s): Pia Mach, Pavel I. Kos, Yinxiu Zhan, Julie Cramard, Simon Gaudin, Jana Tünnermann, Edoardo Marchi, Jan Eglinger, Jessica Zuin, Mariya Kryzhanovska, Sebastien Smallwood, Laurent Gelman, Gregory Roth, Elphège P. Nora, Guido Tiana & Luca Giorgetti
Published in: Nature Genetics, Issue 54, 2022, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-022-01232-7

The Trithorax group protein ASH1 requires a combination of BAH domain and AT hooks, but not the SET domain, for mitotic chromatin binding and survival

Author(s): Philipp A. Steffen; Christina Altmutter; Eva Dworschak; Sini Junttila; Attila Gyenesei; Xinzhou Zhu; Tobias Kockmann; Leonie Ringrose
Published in: Chromosoma, Issue 1, 2021, ISSN 0009-5915
Publisher: Springer Verlag
DOI: 10.3929/ethz-b-000500204

Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding

Author(s): Mattia Conte, Ehsan Irani, Andrea M. Chiariello, Alex Abraham, Simona Bianco, Andrea Esposito & Mario Nicodemi
Published in: Nature Communications, Issue 13, 4070, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-31856-6

The needle and the haystack: single molecule tracking to probe the transcription factor search in eukaryotes

Author(s): Matteo Mazzocca, Tom Fillot, Alessia Loffreda, Daniela Gnani, Davide Mazza
Published in: Biochemical Society Transactions, 2021, ISSN 0300-5127
Publisher: Portland Press, Ltd.
DOI: 10.1042/bst20200709

Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent

Author(s): Kim Sneppen, Leonie Ringrose
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-10130-2

MGcount: a total RNA-seq quantification tool to address multi-mapping and multi-overlapping alignments ambiguity in non-coding transcripts

Author(s): Andrea Hita, Gilles Brocart, Ana Fernandez, Marc Rehmsmeier, Anna Alemany and Sol Schvartzman
Published in: BMC Bioinformatics, 2022, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-021-04544-3

The transcription factor Atf1 lowers the transition barrier for nucleosome-mediated establishment of heterochromatin

Author(s): Nickels, J. F., Della-Rosa, M. E., Goyeneche, I. M., Charlton, S. J., Sneppen, K., & Thon, G.
Published in: Cell Reports, Issue 39(7), 110828, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110828

Integrating analog and digital modes of gene expression at Arabidopsis FLC

Author(s): Rea L. Antoniou-Kourounioti, Anis Meschichi, Svenja Reeck, Scott Berry, Govind Menon, Yusheng Zhao, John A. Fozard, Terri L. Holmes, Huamei Wang, Matthew Hartley, Caroline Dean, Stefanie Rosa, Martin Howard
Published in: eLife, Issue 12, e79743, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2022.07.04.498694

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