Description du projet
Un dispositif photonique portable et à faible coût pourrait améliorer le diagnostic précoce des maladies cardiovasculaires
Selon l’Organisation mondiale de la santé, les maladies cardiovasculaires sont la principale cause de décès dans le monde, avec près de 18 millions de décès par an. Comme pour de nombreuses pathologies, le diagnostic et l’intervention précoces peuvent sauver des vies. Des changements dans la circulation sanguine peuvent indiquer des anomalies dans la manière dont le cœur se contracte pour pomper le sang, ainsi que des modifications du diamètre artériel ou de l’élasticité, autant de signes avant-coureurs d’une maladie cardiovasculaire. Le projet InSiDe, financé par l’UE, développe un interféromètre à laser Doppler portable exploitant la photonique sur silicium et des algorithmes efficaces afin de fournir en temps réel une analyse du signal des paramètres cardiovasculaires sélectionnés. Ce dispositif de surveillance de haute technologie à faible coût répondra à un besoin insatisfait en ayant d’importantes implications pour les patients et les systèmes de soins de santé.
Objectif
The rationale for Medtronic and partners to propose the InSiDe project is the unmet need of the medical community for reliable, non-invasive, cheap and easy-to-use tools able to identify and characterize different stages of cardiovascular diseases. Solving this need ensures the early adoption of the appropriate therapies, dramatically reduces healthcare costs and importantly, improves patient outcome.
In fact, monitoring arterial stiffness by measurement of the aortic pulse wave velocity has been demonstrated to be a crucial need for the management of hypertensive patients and it is recommended in the European Society of Cardiology Guidelines. In addition, the early identification of arterial stenosis and cardiac contraction abnormalities can be used to drive earlier therapy adoption and to improve patient’s response in cardiac (valvular) disease.
Building on the realizations of the successful CARDIS (H2020-ICT-644798) project, the objective of InSiDe is to accelerate access to a new diagnostic device, based on silicon photonics technology, able to monitor cardiovascular diseases and to prove its efficacy in driving a timely therapy institution and its related follow-up.
We will:
-Develop an efficient miniaturized laser Doppler interferometer supported by a manufacturable package with integrated imaging optics and by electronics for control of the laser interferometer with onboard near-real time signal processing capability.
-Develop algorithms for translation of the interferometer signals to beat-to-beat measurement results relevant for monitoring and diagnosis of selected cardiovascular parameters.
-Prove the device efficacy in multiple clinical feasibility studies inside and outside the consortium.
-Outline a path to industrialization and manufacturability.
In this way InSiDe will realize a low-cost handheld, robust diagnostic tool, manufacturable in high-volumes. The diagnostic tool gives immediate results for physician’s interpretation.
Champ scientifique
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsignal processing
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- natural scienceschemical sciencesinorganic chemistrymetalloids
- natural sciencesphysical sciencesopticslaser physics
Mots‑clés
Programme(s)
Régime de financement
IA - Innovation actionCoordinateur
3001 Leuven
Belgique