Descrizione del progetto
Un dispositivo fotonico portatile a basso costo potrebbe migliorare la diagnosi precoce delle malattie cardiovascolari
Secondo l’Organizzazione mondiale della sanità, le malattie cardiovascolari sono la prima causa di morte a livello globale, associate a quasi 18 milioni di morti ogni anno. Come per la maggior parte delle condizioni, diagnosi e interventi precoci possono salvare delle vite. Eventuali cambiamenti nel flusso sanguigno possono essere indicativi di anomalie nel modo in cui il cuore si contrae per pompare il sangue, nonché di cambiamenti nel diametro o nell’elasticità delle arterie, tutte avvisaglie di malattie cardiovascolari. Il progetto InSiDe, finanziato dall’UE, sta sviluppando un interferometro Doppler laser portatile che sfrutta la fotonica del silicio e algoritmi efficienti per fornire analisi del segnale in tempo reale di parametri cardiovascolari selezionati. Questo dispositivo di monitoraggio ad alta tecnologia a basso costo soddisferà un’esigenza insoddisfatta con importanti implicazioni per i pazienti e i sistemi sanitari.
Obiettivo
The rationale for Medtronic and partners to propose the InSiDe project is the unmet need of the medical community for reliable, non-invasive, cheap and easy-to-use tools able to identify and characterize different stages of cardiovascular diseases. Solving this need ensures the early adoption of the appropriate therapies, dramatically reduces healthcare costs and importantly, improves patient outcome.
In fact, monitoring arterial stiffness by measurement of the aortic pulse wave velocity has been demonstrated to be a crucial need for the management of hypertensive patients and it is recommended in the European Society of Cardiology Guidelines. In addition, the early identification of arterial stenosis and cardiac contraction abnormalities can be used to drive earlier therapy adoption and to improve patient’s response in cardiac (valvular) disease.
Building on the realizations of the successful CARDIS (H2020-ICT-644798) project, the objective of InSiDe is to accelerate access to a new diagnostic device, based on silicon photonics technology, able to monitor cardiovascular diseases and to prove its efficacy in driving a timely therapy institution and its related follow-up.
We will:
-Develop an efficient miniaturized laser Doppler interferometer supported by a manufacturable package with integrated imaging optics and by electronics for control of the laser interferometer with onboard near-real time signal processing capability.
-Develop algorithms for translation of the interferometer signals to beat-to-beat measurement results relevant for monitoring and diagnosis of selected cardiovascular parameters.
-Prove the device efficacy in multiple clinical feasibility studies inside and outside the consortium.
-Outline a path to industrialization and manufacturability.
In this way InSiDe will realize a low-cost handheld, robust diagnostic tool, manufacturable in high-volumes. The diagnostic tool gives immediate results for physician’s interpretation.
Campo scientifico
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsignal processing
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- natural scienceschemical sciencesinorganic chemistrymetalloids
- natural sciencesphysical sciencesopticslaser physics
Parole chiave
Programma(i)
Meccanismo di finanziamento
IA - Innovation actionCoordinatore
3001 Leuven
Belgio