Objetivo The neural circuits underlying the formation of functional networks in the cerebral cortex constitute one of the most complex physical systems in the World. Much of this complexity arises during development through the interaction of two distinct neuronal types, glutamatergic projection neurons and aminobutyric containing (GABAergic) interneurons.Recently, interneuron dysfunction has been associated with severe neurological and psychiatric disorders (e.g. epilepsy, schizophrenia and bipolar disorder). In order to achieve true progress in the understanding of cortical development and of neurological diseases associated with cortical dysfunction, a complete account of the development of its neuronal constituents is essential.In that sense, despite the detailed picture that is emerging about the development of cortical projection neurons, the mechanisms underlying the development of interneurons in the cerebral cortex have remained poorly defined. The general goal of this project is to obtain a comprehensive definition of the cellular and molecular mechanisms controlling the development of cortical interneurons.To reach this aim, I propose to take a multidisciplinary approach by combining mouse genetics, novel genomic applications, cutting-edge imaging techniques, and conventional cellular and molecular biology methodologies. In addition, I will develop new genetic tools to engineer developmental models of cortical disorders involving interneuron deficiency.Thus, successful execution of the project will result in:i) New knowledge of the mechanisms underlying the specification, migration and differentiation of cortical interneurons, andii) Generation of new developmental models of cortical disorders resulting from interneuron deficiency. Ámbito científico natural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicineneurologyepilepsymedical and health sciencesclinical medicinepsychiatryschizophrenianatural sciencesbiological sciencesmolecular biology Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-2.3R - Marie Curie Incoming International Fellowships (IIF), Re-integration phase Convocatoria de propuestas FP6-2005-MOBILITY-7 Consulte otros proyectos de esta convocatoria Régimen de financiación IIF - Marie Curie actions-Incoming International Fellowships Coordinador INSTITUTE FOR GENETIC ENGENIERING AND MOLECULAR BIOLOGY Aportación de la UE Sin datos Dirección Vuelta de Obligado 2490 BUENOS AIRES Argentina Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos
