Objetivo To demonstrate the safety and practicability of boron neutron capture therapy (BNCT) as radiotherapy modality.To demonstrate which are the optimal treatment conditions for glioma treatment with boron neutron capture therapy and Na2B12H11SH (BSH) as boron carrier.To demonstrate the use of a centralized European treatment center in multi-country treatment.The proposed Demonstration Project is for a Phase I/II study of glioma treatment with boron neutron capture therapy (BNCT). It has as objective to investigate whether BNCT with epithermal neutrons and Na2B12HllSH (BSH) as boron compound is a safe, and an effective, treatment of glioma. This will be achieved through the treatment of patients, with patient survival and quality of survival as measurable parameters. The study will show what the maximum irradiation level is for safe BNCT with BSH, and whether irradiation at or before maximum tolerated dose will result in partial or complete tumour control. It will be investigated to which extent treatment conditions can influence the outcome for the patients. Emphasis will be put on safety for the patient and effectiveness of treatment. The program will eventually demonstrate whether the therapeutic ratio of BNCT can surpass that of other radiotherapy modalities for glioma. Thus, it falls within area 4.1 Cancer Research subsection 4.1.8 Assessment of treatment modalities. If successful, it will lead to the introduction of a new cancer therapy modality into the clinical reality. The clinical research proposed will therefore facilitate the transition of BNCT into clinical use. It can only be carried out in the framework of a Demonstration Project. Europe has, among the participating partners, all necessary knowledge and experience to carry out the project in a competent and effective manner. Ámbito científico medical and health sciencesclinical medicineoncologynatural scienceschemical sciencesinorganic chemistrymetalloids Programa(s) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Tema(s) 8.2 - Demonstration Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador UNIVERSITAET BREMEN Aportación de la UE Sin datos Dirección Leobener Strasse 28334 Bremen Alemania Ver en el mapa Coste total Sin datos Participantes (8) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS Suiza Aportación de la UE Sin datos Dirección Rue du Bugnon 46 1011 LAUSANNE Ver en el mapa Coste total Sin datos Centre Antoine Lacassagne Francia Aportación de la UE Sin datos Dirección 227,Avenue de la Lanterne 06200 Nice Ver en el mapa Coste total Sin datos Commission of the European Communities Países Bajos Aportación de la UE Sin datos Dirección 3,Westerduinweg 1755 ZG Petten Ver en el mapa Coste total Sin datos Karl-Franzens-Universität Graz Austria Aportación de la UE Sin datos Dirección Auenbruggerplatz 8036 Graz Ver en el mapa Coste total Sin datos Ludwig-Maximilians-Universität München Alemania Aportación de la UE Sin datos Dirección 15,Marchioninistraße 81366 München Ver en el mapa Coste total Sin datos Netherlands Energy Research Foundation Países Bajos Aportación de la UE Sin datos Dirección 3,Westerduinweg 1755 LE Petten Ver en el mapa Coste total Sin datos Universität Gesamthochschule Essen Alemania Aportación de la UE Sin datos Dirección 55,Hufelandstrasse 45122 Essen Ver en el mapa Coste total Sin datos Zentralkrankenhaus St.-Jürgen-Strasse Alemania Aportación de la UE Sin datos Dirección St.-Jürgen-Strasse 28205 Bremen Ver en el mapa Coste total Sin datos