Objetivo Leishmania are obligate intracellular parasites that cause a spectrum of diseases called leishmaniasis ranging from self healing skin ulcers to a fatal visceral infection. Only a few drugs are available for treatment of leishmaniasis and consequently, there is a need for new drugs. Among them the polyene antibiotic Amphotericin B (AmB) can be useful in the treatment of visceral and mucosal leishmaniasis, and is the most common drug for the treatment of fungal diseases.This research project is to determine whether the liposomal formulations proposed for fungal diseases can be applied to leishmaniasis and, if so, whether they can be improved. AmB is generally assumed to act at the plasma membrane level of the parasite, by perturbing the membrane permeability. The study will determine the binding of AmB to plasma membranes of Leishmania in promastigote or amastigote form, or macrophages or tubular renal cells, and its consequences for the transmembrane permeability and the viability of the cells. Programa(s) IC-ISC C - Activity (Euratom, EEC) on cooperation in science and technology, 1984- Tema(s) Data not available Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador UNIVERSITE PIERRE ET MARIE CURIE - PARIS VI Aportación de la UE Sin datos Dirección Place Jussieu 4 75252 PARIS Francia Ver en el mapa Coste total Sin datos Participantes (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Universidad Central de Venezuela Venezuela Aportación de la UE Sin datos Dirección Zona Rental Plaza Venezuela 1020 Caracas Ver en el mapa Coste total Sin datos
