CYTOGENETIC RESEARCH TO INVESTIGATE SOMATIC AND GERMINAL DAMAGE

Ziel

ELABORATION AND COMPARATIVE EVALUATION OF TEST SYSTEMS FOR THE ASSESSMENT OF GENETIC EFFECTS OF ENVIRONMENTAL CHEMICALS AND OF THE PRODUCTS OF THEIR METABOLIC TRANSFORMATION.

THE AIM OF THIS PROJECT IS TO STUDY THE CYTOGENETIC DAMAGE (SISTER-CHROMATID EXCHANGES AND CHROMOSOMAL ABERRATIONS) INDUCED BY VARIOUS CONCENTRATIONS OF DIRECT AND INDIRECT-ACTING CHEMICAL MUTAGENS ON PROLIFERATING TISSUES (BONE-MARROW, SPLEEN AND SPERMATOGONIA) AND LYMPHOCYTES STIMULATED IN VITRO OF MICE TREATED IN VIVO. PARTICULAR ATTENTION WILL BE GIVEN TO THE DIFFERENT SENSITIVITY OF GERMINAL TISSUES IN RESPECT TO SOMATIC ONES TRYING TO CORRELATE THIS DIFFERENCE TO THE METABOLISM OF THE MUTAGENS AND THE REPAIR INDUCTION PRESENT IN THE VARIOUS TISSUES.

Programm/Programme

PRE-ENVPROT 3C - Sectoral research and development programme (EEC) in the field of environment (environmental protection and climatology) - indirect and concerted actions - Environmental protection -, 1981-1985

Thema/Themen

Data not available

Aufforderung zur Vorschlagseinreichung

Data not available

Finanzierungsplan

CSC - Cost-sharing contracts

Koordinator

Consiglio Nazionale delle Ricerche (CNR)

EU-Beitrag

Keine Daten

Adresse

Città Universitaria Piazzale Aldo Moro 5
00185 Roma
Italien

Gesamtkosten