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Role of the ph-domain in regulating pdk1 activity

Objectif

I propose to generate a PDK1 knocking mouse embryonic stem cell line that expresses a mutated form of DKP1 which PH-domain can not interact with PtdIns (3,4,5)P3. The study of this cell line will permit to further understand the mechanism by which PtdIns(3,4,5)P_3 regulates the insulin signal transduction

Thème(s)

Data not available

Appel à propositions

Data not available

Coordinateur

UNIVERSITY OF DUNDEE
Contribution de l’UE
Aucune donnée
Adresse
Nethergate
DD1 4HN DUNDEE
Royaume-Uni

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Coût total
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