Objetivo Malaria vaccines are urgently required. Recombinant multi-component cocktail vaccines are currently favoured. Using very recent technological advances this programme revives the concept of attenuated parasites as vaccines. It bring together for the first leading EU and African groups to develop methodologies allowing the design and creation of parasites with properties desirable in such a vaccine. The ultimate delivery of such a vaccine may be as either sexually incompetent, genetically restricted parasites, or as transmissible self-spreading forms. For either route certain fundamental pre-conditions must be met, and these are the major focus of this proposal; Systems will be developed to provide1) auxotrophic parasites2) sequential unrestricted genetic manipulation of parasites3) axenic culture4) parasite knock outs for specific genes and5) immuno-potentiated parasites through heterologous gene expression. In combination with a dialogue across scientific and public interests this programme will enable the partnership to provide a clear assessment of the feasibility of vaccination with genetically modified malaria within three years. Ámbito científico medical and health scienceshealth sciencesinfectious diseasesmalariamedical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programa(s) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Tema(s) Data not available Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador LEIDEN UNIVERSITY Aportación de la UE Sin datos Dirección Wassenaarseweg 72 2333 AL LEIDEN Países Bajos Ver en el mapa Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE Países Bajos Aportación de la UE Sin datos Dirección 151,Lange Kleiweg 151 2280 GH RIJSWIJK ZH Ver en el mapa Coste total Sin datos MED BIOTECH LABORATORIES Uganda Aportación de la UE Sin datos Dirección Sekindi Close Plot 3438 - Myenga 10 KAMPALA Ver en el mapa Coste total Sin datos UNIVERSITAETSKLINIKUM HEIDELBERG Alemania Aportación de la UE Sin datos Dirección Im Neuenheimer Feld 324 69120 Heidelberg Ver en el mapa Coste total Sin datos UNIVERSITY COLLEGE OF IBADAN Nigeria Aportación de la UE Sin datos Dirección University College Hospital IBADAN Ver en el mapa Coste total Sin datos
