Cel Neff is a lent viral protein critical for AIDS pathogenesis. In addition to increasing HIV replication, Net has an independent role as a major pathogenicityfactor, as revealed by recent work in transgenic mice. This two-fold contribution of Neff to the pathogenesis of AIDS suggests that compounds that could block Neff unction would be potent anti-AIDS drugs. Despite this remarkable promise, Neff has so far not been exploited as a therapeutic target. The objective of the proposed collaborative project is to extend the ongoing basic research in the individual laboratories of this consortium towards the common and more applied goal of transforming Neff into a therapeutic target that would be attractive and readily available to the pharmaceutical industry for exploitation in drug discovery, goal that conforms well to objectives of the thematic priority 1.1.1. -2.2.1 of thee Fifth Framework Programme. Dziedzina nauki medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIV Program(-y) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Temat(-y) 1.1.1.-2. - Key action Control of Infectious Diseases Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator UNIVERSITY OF TAMPERE Wkład UE Brak danych Adres 6,Lenkkeilijänkatu 6 33014 TAMPERE Finlandia Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (4) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko INSTITUT PASTEUR Francja Wkład UE Brak danych Adres Rue du Docteur Roux 25 75724 PARIS Zobacz na mapie Koszt całkowity Brak danych UNIVERSITAETSKLINIKUM HEIDELBERG Niemcy Wkład UE Brak danych Adres Im Neuenheimer Feld 324 69120 HEIDELBERG Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF ERLANGEN-NUREMBERG Niemcy Wkład UE Brak danych Adres 14,Hartmannstrasse 14 91052 Erlangen Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF LEEDS Zjednoczone Królestwo Wkład UE Brak danych Adres Thoresby Place LS2 9JT Leeds Zobacz na mapie Koszt całkowity Brak danych
