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Modulation of foldases for oversproduction of heterologous proteins in streptomycess

Objectif

Improving the yield of correctly folded heterologous proteins which contain disulfide bonds by stroptomyces lividans may require the assistance of thioldisulfide oxyreductases. As a model the role of various protein disulfide isomerases in the expression and secretion of the h. Medicinalis thrombin inhibitor hirudin will be studied.

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Coordinateur

JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT
Contribution de l’UE
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Adresse
11,Marie-Curie-Strasse 11
60439 FRANKFURT AM-MAIN
Allemagne

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