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CORDIS

The role of rak kinases in malignant transformation in vivo and in vitro.

Objective

Ample evidence suggests that the cryptozoic kinesis Raff-1 and B-Raff are key players in regulated and deregulated proliferation. I plan to use conventional and conditional gene ablation to study the role(s) of these molecules in established transformation models in vivo and in vitro.

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