Objective DNA replication is a key process involved in cell division of all living creatures. Based on the structural and functional homology between archaic andeukaryotes, this project proposes to co-ordinate efforts of one SME and seven laboratories from five European countries on the characterisation of DNAreplication components, DNA Polyrnerases, accessory proteins, both in archaic and Human. Each step of DNA replication will be investigated, initiation, elongation and processing of the lagging strand in order(I) to understand the basic mechanisms at each level,(ii) to isolate novel proteins and enzymes and(iii) to increase the probability of finding new products and key residues. Two fields of application are concerned:molecular biology products in vitro amplification and health with novel DNA replication inhibitors Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymesnatural sciencesbiological sciencesmolecular biology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator IFREMER - INSTITUT FRANÇAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER EU contribution No data Address Rue Jean-Jacques Rousseau 155, Technopolis 40 92138 ISSY LES MOULINEAUX France See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Rue Michel Ange 3 75794 PARIS See on map Links Website Opens in new window Total cost No data KAROLINSKA INSTITUTE Sweden EU contribution No data Address 6,Blickagangen 6 141 57 HUDDINGE See on map Total cost No data NATIONAL RESEARCH COUNCIL OF ITALY Italy EU contribution No data Address Piazzale Aldo Moro 7 00185 ROMA See on map Total cost No data UNIVERSITE DE PARIS-SUD XI France EU contribution No data Address RUE GEORGES CLEMENCEAU 15 91405 ORSAY See on map Total cost No data UNIVERSITY OF ZURICH Switzerland EU contribution No data Address 71,Raemistrasse 71 CH-8091 ZURICH See on map Total cost No data
