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DNA replication and biotechnological applications

Objective

DNA replication is a key process involved in cell division of all living creatures. Based on the structural and functional homology between archaic andeukaryotes, this project proposes to co-ordinate efforts of one SME and seven laboratories from five European countries on the characterisation of DNAreplication components, DNA Polyrnerases, accessory proteins, both in archaic and Human. Each step of DNA replication will be investigated, initiation, elongation and processing of the lagging strand in order
(I) to understand the basic mechanisms at each level,
(ii) to isolate novel proteins and enzymes and
(iii) to increase the probability of finding new products and key residues. Two fields of application are concerned:
molecular biology products in vitro amplification and health with novel DNA replication inhibitors

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

IFREMER - INSTITUT FRANÇAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER
Address
Rue Jean-jacques Rousseau 155, Technopolis 40
92138 Issy Les Moulineaux
France

Participants (5)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel Ange 3
75794 Paris
KAROLINSKA INSTITUTE
Sweden
Address
6,Blickagangen 6
141 57 Huddinge
NATIONAL RESEARCH COUNCIL OF ITALY
Italy
Address
Piazzale Aldo Moro 7
00185 Roma
UNIVERSITE DE PARIS-SUD XI
France
Address
Rue Georges Clemenceau 15
91405 Orsay
UNIVERSITY OF ZURICH
Switzerland
Address
71,Raemistrasse 71
CH-8091 Zurich