Objective The project aim is to provide new toxicological and epidemiological data to improve the risk assessment of dioxin and other food-derived endocrine disrupting chemicals (EDC). Focus is to clarify mechanisms behind functional diseases (osteoporosis) and structural malformations induced by EDCs through interactions with components of the nuclear receptor signalling pathways and other cell regulatory systems. We will address the hormonal cross-talk between Ah receptor (dioxin), retinoid as well as steroid hormone (estrogen) signalling pathways. Objectives will be achieved through the use of genetically modified animal models, gene array technology, proteomic and bioinformatic analysis, as well as traditional biomedical methods, and epidemiological studies. Obtained results will be used for(i) test method and biomarker development and for(ii) risk assessment purposes. Fields of science medical and health sciencesbasic medicinetoxicology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-4. - Key action Environment and Health Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator KAROLINSKA INSTITUTE EU contribution No data Address Nobels Vaeg, 13 171 77 STOCKHOLM Sweden See on map Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Rue Michel Ange 3 75794 PARIS See on map Links Website Opens in new window Total cost No data GOETEBORG UNIVERSITY Sweden EU contribution No data Address Vasaparken 405 30 GOETEBORG See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address Rue de Tolbiac, 101 75654 PARIS See on map Total cost No data MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH Italy EU contribution No data Address Via Eritrea 62 20157 MILANO See on map Total cost No data NATIONAL PUBLIC HEALTH INSTITUTE Finland EU contribution No data Address Neulaniementie 4 70701 KUOPIO See on map Total cost No data SCHOOL OF VETERINARY MEDICINE, HANNOVER Germany EU contribution No data Address Buenteweg 17 30559 HANNOVER See on map Total cost No data UNIVERSITE LOUIS PASTEUR, STRASBOURG 1 France EU contribution No data Address Rue Blaise Pascal 4 67070 STRASBOURG See on map Total cost No data UNIVERSITY OF OULU Finland EU contribution No data Address Pentti Kaiterankatu 1 90014 OULU See on map Links Website Opens in new window Total cost No data