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Bone development and homeostasis-critical targets in toxicology. Research to support test-method development and human health risk assessment for dioxins and other endocrine disrupting compounds in the food chain

Objective

The project aim is to provide new toxicological and epidemiological data to improve the risk assessment of dioxin and other food-derived endocrine disrupting chemicals (EDC). Focus is to clarify mechanisms behind functional diseases (osteoporosis) and structural malformations induced by EDCs through interactions with components of the nuclear receptor signalling pathways and other cell regulatory systems. We will address the hormonal cross-talk between Ah receptor (dioxin), retinoid as well as steroid hormone (estrogen) signalling pathways. Objectives will be achieved through the use of genetically modified animal models, gene array technology, proteomic and bioinformatic analysis, as well as traditional biomedical methods, and epidemiological studies. Obtained results will be used for
(i) test method and biomarker development and for
(ii) risk assessment purposes.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

KAROLINSKA INSTITUTE
Address
Nobels Vaeg, 13
171 77 Stockholm
Sweden

Participants (8)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel Ange 3
75794 Paris
GOETEBORG UNIVERSITY
Sweden
Address
Vasaparken
405 30 Goeteborg
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Tolbiac, 101
75654 Paris
MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH
Italy
Address
Via Eritrea 62
20157 Milano
NATIONAL PUBLIC HEALTH INSTITUTE
Finland
Address
Neulaniementie 4
70701 Kuopio
SCHOOL OF VETERINARY MEDICINE, HANNOVER
Germany
Address
Buenteweg 17
30559 Hannover
UNIVERSITE LOUIS PASTEUR, STRASBOURG 1
France
Address
Rue Blaise Pascal 4
67070 Strasbourg
UNIVERSITY OF OULU
Finland
Address
Pentti Kaiterankatu 1
90014 Oulu