The project aim is to provide new toxicological and epidemiological data to improve the risk assessment of dioxin and other food-derived endocrine disrupting chemicals (EDC). Focus is to clarify mechanisms behind functional diseases (osteoporosis) and structural malformations induced by EDCs through interactions with components of the nuclear receptor signalling pathways and other cell regulatory systems. We will address the hormonal cross-talk between Ah receptor (dioxin), retinoid as well as steroid hormone (estrogen) signalling pathways. Objectives will be achieved through the use of genetically modified animal models, gene array technology, proteomic and bioinformatic analysis, as well as traditional biomedical methods, and epidemiological studies. Obtained results will be used for
(i) test method and biomarker development and for
(ii) risk assessment purposes.
Funding SchemeCSC - Cost-sharing contracts
405 30 Goeteborg