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Content archived on 2024-05-24

Bone development and homeostasis-critical targets in toxicology. Research to support test-method development and human health risk assessment for dioxins and other endocrine disrupting compounds in the food chain

Objective

The project aim is to provide new toxicological and epidemiological data to improve the risk assessment of dioxin and other food-derived endocrine disrupting chemicals (EDC). Focus is to clarify mechanisms behind functional diseases (osteoporosis) and structural malformations induced by EDCs through interactions with components of the nuclear receptor signalling pathways and other cell regulatory systems. We will address the hormonal cross-talk between Ah receptor (dioxin), retinoid as well as steroid hormone (estrogen) signalling pathways. Objectives will be achieved through the use of genetically modified animal models, gene array technology, proteomic and bioinformatic analysis, as well as traditional biomedical methods, and epidemiological studies. Obtained results will be used for
(i) test method and biomarker development and for
(ii) risk assessment purposes.

Call for proposal

Data not available

Coordinator

KAROLINSKA INSTITUTE
EU contribution
No data
Address
Nobels Vaeg, 13
171 77 STOCKHOLM
Sweden

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Total cost
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Participants (8)