Objective T-CIA will investigate basic processes of physiological ageing of human T lymphocytes. Partners will contribute samples from young and old, very healthy and less healthy donors, and in vitro cultured cells, which will be redistributed for analysis using proteomics, genomics, DNA damage and repair assessment, antigen receptor repertoire, T cell surface markers and function, apoptosis and proliferation control, and immunogenetic studies. Biomarkers selected as relevant to immune ageing rather than resulting from underlying disease or culturing will be recommended for monitoring intervention studies. T-CIA interventions will be on T cell clones is tissue culture, using anti-oxidants, antisense approaches, h-TERT and HSP gene transfection, cytokine and hormone cocktails etc., and will result in recommendations for in vivo intervention. Biomarker monitoring and anti-ageing interventions are potentially marketable by the industrial partner. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencesgeneticsDNA Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator THE UNIVERSITY OF TUEBINGEN EU contribution No data Address Waldhoernlestrasse 22 72072 TUEBINGEN Germany See on map Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all MEDICAL UNIVERSITY HOSPITAL ALEKSANDROVSKA Bulgaria EU contribution No data Address Georgi Sofiiski Street 1 1431 SOFIA See on map Total cost No data SCHOOL OF HEALTH SCIENCES Sweden EU contribution No data Address BARNARPSGATAN 39 551 11 JOENKOEPING See on map Total cost No data THE NOTTINGHAM TRENT UNIVERSITY United Kingdom EU contribution No data Address Clifton Lane NG11 8NS NOTTINGHAM See on map Total cost No data UNILEVER UK CENTRAL RESOURCES LTD United Kingdom EU contribution No data Address Colworth House, Sharnbrook MK44 1LQ CARDINGTON,BEDFORD See on map Total cost No data UNIVERSIDAD DE CORDOBA Spain EU contribution No data Address Avda Menendez Pidal s/n 14004 CORDOBA See on map Total cost No data UNIVERSITY OF BOLOGNA Italy EU contribution No data Address Via Tolara di Sopra 50 40064 OZZANO DELL EMILIA See on map Total cost No data UNIVERSITY OF ULSTER United Kingdom EU contribution No data Address Cromore Road BT52 1SA COLERAINE See on map Total cost No data
