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T cell immunity and ageing

Objective

T-CIA will investigate basic processes of physiological ageing of human T lymphocytes. Partners will contribute samples from young and old, very healthy and less healthy donors, and in vitro cultured cells, which will be redistributed for analysis using proteomics, genomics, DNA damage and repair assessment, antigen receptor repertoire, T cell surface markers and function, apoptosis and proliferation control, and immunogenetic studies. Biomarkers selected as relevant to immune ageing rather than resulting from underlying disease or culturing will be recommended for monitoring intervention studies. T-CIA interventions will be on T cell clones is tissue culture, using anti-oxidants, antisense approaches, h-TERT and HSP gene transfection, cytokine and hormone cocktails etc., and will result in recommendations for in vivo intervention. Biomarker monitoring and anti-ageing interventions are potentially marketable by the industrial partner.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

THE UNIVERSITY OF TUEBINGEN
Address
Waldhoernlestrasse 22
72072 Tuebingen
Germany

Participants (7)

MEDICAL UNIVERSITY HOSPITAL ALEKSANDROVSKA
Bulgaria
Address
Georgi Sofiiski Street 1
1431 Sofia
SCHOOL OF HEALTH SCIENCES
Sweden
Address
Barnarpsgatan 39
551 11 Joenkoeping
THE NOTTINGHAM TRENT UNIVERSITY
United Kingdom
Address
Clifton Lane
NG11 8NS Nottingham
UNILEVER UK CENTRAL RESOURCES LTD
United Kingdom
Address
Colworth House, Sharnbrook
MK44 1LQ Cardington,bedford
UNIVERSIDAD DE CORDOBA
Spain
Address
Avda Menendez Pidal S/n
14004 Cordoba
UNIVERSITY OF BOLOGNA
Italy
Address
Via Tolara Di Sopra 50
40064 Ozzano Dell Emilia
UNIVERSITY OF ULSTER
United Kingdom
Address
Cromore Road
BT52 1SA Coleraine