Objective Titin is the largest polypeptide yet described and an abundant constituent muscle. Its function and properties are to be investigated in an integrated study at both the protein and gene levels. At the protein level, X-ray diffraction of ordered fibres of purified titin will provide information about the folding of the polypeptide chain and the molecular mechanism of shape changes. At the nucleic acid level, the cloning will allow the analysis of the structure of the gene and its transcriptional organisation. The exact locations of particular sections of sequence will be determined in labelling studies using relation of titin to other proteins and its possible involvement in genetic diseases to be explored. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acidsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP2-SCIENCE - Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator EUROPEAN MOLECULAR BIOLOGY LABORATORY EU contribution No data Address Meyerhofstrasse 1 HEIDELBERG Germany See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all FORSCHUNGSINSTITUT FUER MOLEKULARE PATHOLOGIE GMBH Austria EU contribution No data Address Dr. Bohr-Gasse 7 1030 WIEN See on map Total cost No data IMPERIAL CANCER RESEARCH FUND United Kingdom EU contribution No data Address Lincoln's Inn Fields 44 WC2A 3PX LONDON See on map Total cost No data Max-Planck-Gesellschaft zur Förderungder Wissenschaften e.V. Germany EU contribution No data Address SpemannstraÙe 72076 Tübingen 1 See on map Total cost No data University of Bristol United Kingdom EU contribution No data Address Langford BS18 7DU Bristol See on map Total cost No data
