Objetivo Understanding the biological signals and their temporal magnitude involved in the division, maturation and migration of haematopoietic stem cells (HSCs) and their differentiated progeny would allow for a controlled continuous production of mature blood cells. By careful selection of a 3-dimensional micro-environment it is possible to mimic the niche within bone marrow in which haematopoiesis occurs. Further, by design and control of the flow profile within this microenvironment, it is possible to fine tune the rate of departure of the differentiating cells into a separate microenvironment suitable for further maturation, so creating the conditions for the generation of mature blood cells which could be a continuous process. This research will determine the requirements for the control of the fluidic behaviour within bioreactors for the generation of HSC. Complex, composite systems that allow for the temporal and spatial separation of microenvironments allowing for not only variation in the fluid flow and oxygen tension, but a change in the chemical nature of the culture conditions, will provide the opportunity for delivery of controlling factors. The principle is based on the ability to provide nutritional exchange with an overall zero, or very small, net mass transport. Mechanical design will allow us to match the rate of HSC division, providing the opportunity to derive the daughter cells into the correct environment for red blood cell development over an appropriate time frame. Differentiation of HSCs into different blood cell types occurs within different bone marrow niches and so mimicry of the erythrocyte niche is likely to result in maximisation of the rate of red blood cell development. Ámbito científico engineering and technologyenvironmental biotechnologybioremediationbioreactorsmedical and health sciencesmedical biotechnologycells technologiesstem cells Programa(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Tema(s) NMP-2008-2.3-1 - Advanced implants and bioactive materials for critical organs Convocatoria de propuestas FP7-NMP-2008-SMALL-2 Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador THE UNIVERSITY OF LIVERPOOL Aportación de la UE € 1 104 518,00 Dirección BROWNLOW HILL 765 FOUNDATION BUILDING L69 7ZX Liverpool Reino Unido Ver en el mapa Región North West (England) Merseyside Liverpool Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Joanne Arthur (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo APPLIKON BIOTECHNOLOGY BV Países Bajos Aportación de la UE € 675 650,00 Dirección HEERTJESLAAN 2 2629 JG Delft Ver en el mapa Región West-Nederland Zuid-Holland Delft en Westland Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Isabelle Debel (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos BANC DE SANG I TEIXITS España Aportación de la UE € 406 680,00 Dirección PASSEIG DE LA VALL D HEBRON 119 08035 BARCELONA Ver en el mapa Tipo de actividad Research Organisations Contacto administrativo Gabriela Marin Cobo (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITAET LEIPZIG Alemania Aportación de la UE € 560 152,00 Dirección RITTERSTRASSE 26 04109 Leipzig Ver en el mapa Región Sachsen Leipzig Leipzig Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Gerhard Fuchs (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
