Objetivo "Chronic pain is prevalent and it causes decreased quality of life and significant costs to the society in terms of lost working capacity. Currently available analgesics are either not effective enough or patients cannot take them due to adverse effects. Non-steroidal anti-inflammatory drugs are a major cause of drug-related morbidity and mortality. Opioids can cause tolerance and addiction when used for long-term management of chronic pain. Analgesic efficacy can be improved by targeting specific mechanisms that are involved in pain processing of specific conditions, e.g. fibromyalgia, osteoarthritis, rheumatoid arthritis, and neuropathic pain, and by improving the safety profile of the current analgesics. This project focuses on the role of glial activation by tissue and nerve injury, inflammation, and opioids in large cohorts of chronic pain patients. We will develop a biomarker profile for the clinical conditions by assessing inflammatory markers in cerebrospinal fluid and glial activation in the brain with PET, by performing well-validated experimental pain tests, and genetics. Interindividual differences in pain perception will be studied using experimental pain tests including activation of descending inhibitions as a biomarker of endogenous analgesia and fMRI. Individual differences with the glial activation and pain perception will be used to design different research lines across the board aiming at developing personalized treatments for pain. We will use well-validated animal models relevant for arthritis, fibromyalgia, and neuropathic pain. Glial activation in these animal models will be studied using novel methodology to better understand the pathophysiology of these conditions. They will also be used as targets for new drug discovery which will focus on the design and synthesis of compounds that block TLR4-mediated activation of glia and also on small compounds that mimic the actions of the GDNF-family." Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesgeneticssocial sciencessociologydemographymortalitymedical and health sciencesclinical medicinerheumatologymedical and health sciencesbasic medicinephysiologypathophysiology Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH.2013.2.2.1-5 - Understanding and controlling pain Convocatoria de propuestas FP7-HEALTH-2013-INNOVATION-1 Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador HELSINGIN YLIOPISTO Aportación de la UE € 2 118 688,50 Dirección YLIOPISTONKATU 3 00014 Helsingin Yliopisto Finlandia Ver en el mapa Región Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Tiina Berg (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo KAROLINSKA INSTITUTET Suecia Aportación de la UE € 2 011 123,20 Dirección Nobels Vag 5 17177 Stockholm Ver en el mapa Región Östra Sverige Stockholm Stockholms län Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Ylva Hultman (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN Alemania Aportación de la UE € 578 396,80 Dirección THEODOR W ADORNO PLATZ 1 60323 Frankfurt Am Main Ver en el mapa Región Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Jörn Lötsch (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE Francia Aportación de la UE € 974 800,00 Dirección Rue Laurent Fries 1 67404 Illkirch Graffenstaden Ver en el mapa Región Grand Est Alsace Bas-Rhin Tipo de actividad Research Organisations Contacto administrativo Steve Brooks (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos CHEMEDEST OU Estonia Aportación de la UE € 314 070,60 Dirección SOOLA 8 51013 TARTU Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Leonid Tolstov (Mr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos