Objetivo Graves' orbitopathy (GO), also known as thyroid eye disease, affects approximately 3 million people in Europe with an estimated socioeconomic burden of 6.4 billion euros per annum. GO is a complication of Graves' disease which is an autoimmune disease and the commonest cause of an overactive thyroid gland. The treatment of GO remains unsatisfactory and the majority of patients report long-term impairment of quality of life. To improve the outcomes of people with GO and thus reduce long-term illness and cost to society, research is needed to address the identification of risk factors, develop a better understanding of the pathophysiology of the disease, devise approaches for early diagnosis during the pre-clinical stage of the disease, and create novel and safe interventions. INDIGO will refine and optimise animal and in vitro models of Graves’ disease and GO, which are urgently required to facilitate the study of the pathogenesis of GO. INDIGO will address the identification of risk factors for the initiation and perpetuation of autoimmunity that causes disease, using the latest generation technologies to study variations in the microbiome in Graves and GO patients and controls. The interaction of the gut derived antigens, from micro-organisms and nutrients on the autoimmune response in both the animal model by probiotic and “contra-biotic” intervention. State of the art technology will be used to search for biomarkers that will identify patients that will progress to GO, during the preclinical phase of the disease when intervention is most likely to be successful. The successful completion of the project will be ensured by a partnership involving 2 SMEs, 3 academic institutions and the European Group on Graves' Orbitopathy, each contributing complementary expertise and technology, the project will involve 5 secondments and 3 recruitments that will facilitate the exchange of knowledge and training. Ámbito científico medical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesbasic medicineimmunologyautoimmune diseasesnatural sciencesbiological sciencesmicrobiology Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2013-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Convocatoria de propuestas FP7-PEOPLE-2013-IAPP Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Coordinador CARDIFF UNIVERSITY Aportación de la UE € 295 392,46 Dirección NEWPORT ROAD 30 36 CF24 0DE Cardiff Reino Unido Ver en el mapa Región Wales East Wales Cardiff and Vale of Glamorgan Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Keith Sexton (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo PARCO TECNOLOGICO PADANO S.R.L. Italia Aportación de la UE € 239 209,86 Dirección Via Einstein - Localita Cascina Codazza 26900 LODI Ver en el mapa Región Nord-Ovest Lombardia Lodi Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Simona Palermo (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITAETSKLINIKUM ESSEN Alemania Aportación de la UE € 108 113,28 Dirección HUFELANDSTRASSE 55 45147 Essen Ver en el mapa Región Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Sebastian George (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos CULTECH LTD Reino Unido Aportación de la UE € 234 886,74 Dirección CHRISTCHURCH ROAD UNIT 2 SA12 7BZ PORT TALBOT WEST GLAMORGAN Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Susan Plummer (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos UNIVERSITA DEGLI STUDI DI MILANO Italia Aportación de la UE € 315 196,20 Dirección Via Festa Del Perdono 7 20122 Milano Ver en el mapa Región Nord-Ovest Lombardia Milano Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Anna Spada (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos