Objective Cancer is a leading health concern. There is a need to fully understand the fundamental processes underlying development of cancer. There is increasing evidence that G protein-coupled receptors (GPCRs) and their associated signalling cascades are involved in both cancer progression and metastasis. As oncogenic GPCRs are likely to be amenable to manipulation via drugs they are ideal therapeutic targets. In ONCORNET (Oncogenic Receptor Network of Excellence and Training) we propose to target two oncogenic GPCRs; the chemokine receptors CXCR4 and CXCR7. These are highly expressed in a range of tumours and yet their role in cancer progression is not well understood. We will focus on unravelling how CXCR4 and CXCR7 are or can be modulated (small molecules, pepducins, nanodies) and investigate the effects on oncogenic responses. This represents crucial knowledge that we currently do not have and yet may well provide potential leads for drug development and commercialisation. ONCORNET will bring together the leading research scientists and labs in Europe with an interest in GPCRs and 15 early stage researchers. We will employ all the latest multidisciplinary research technologies to understand the role of these GPCRs in cancer and develop CXCR4 and CXCR7 tools for diagnostic and therapeutic purposes. Importantly, developed approaches can be extrapolated to other oncogenic GPCRs. The ONCORNET consortium will offer an extensive multidisciplinary training programme to the ESRs to ensure that they can operate in today’s drug discovery programmes. This will include both research (e.g. drug discovery, proteomics, imaging, modelling) and transferable (e.g. entrepreneurship, writing, media training) skill sets –that is rarely offered at PhD level. We will train ESRs to develop the next generation of multidisciplinary scientists with skills that are highly demanded by many of today’s employers in drug development industries. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicssocial scienceseconomics and businessbusiness and managemententrepreneurshipmedical and health sciencesclinical medicineoncologymedical and health scienceshealth sciencesinfectious diseasesDNA viruses Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers Topic(s) MSCA-ITN-2014-ETN - Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) Call for proposal H2020-MSCA-ITN-2014 See other projects for this call Funding Scheme MSCA-ITN-ETN - European Training Networks Coordinator STICHTING VU Net EU contribution € 510 748,56 Address DE BOELELAAN 1105 1081 HV Amsterdam Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 510 748,56 Participants (9) Sort alphabetically Sort by Net EU contribution Expand all Collapse all THE UNIVERSITY OF NOTTINGHAM United Kingdom Net EU contribution € 546 575,76 Address University Park NG7 2RD Nottingham See on map Region East Midlands (England) Derbyshire and Nottinghamshire Nottingham Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 546 575,76 UNIVERSITY OF GLASGOW United Kingdom Net EU contribution € 546 575,76 Address UNIVERSITY AVENUE G12 8QQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 546 575,76 JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG Germany Net EU contribution € 498 432,96 Address SANDERRING 2 97070 Wuerzburg See on map Region Bayern Unterfranken Würzburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 498 432,96 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 525 751,20 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 525 751,20 MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Participation ended Germany Net EU contribution € 0,00 Address HOFGARTENSTRASSE 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Net EU contribution € 512 091,89 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 512 091,89 UNIVERSIDAD AUTONOMA DE MADRID Spain Net EU contribution € 247 872,96 Address CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO 28049 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 247 872,96 ARGEN-X Belgium Net EU contribution € 250 560,00 Address TECHNOLOGIEPARK 30 B-9052 ZWIJNAARDE See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 250 560,00 GRIFFIN DISCOVERIES BV Netherlands Net EU contribution € 255 374,28 Address DE BOEDELAAN 1083 1081HV AMSTERDAM See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 255 374,28 Partners (6) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. ACTELION PHARMACEUTICALS LTD Switzerland Net EU contribution € 0,00 Address GEWERBESTRASSE 16 4123 ALLSCHWIL See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Landschaft Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. ALMAC SCIENCES LIMITED United Kingdom Net EU contribution € 0,00 Address ALMAC HOUSE - SEAGOE INDUSTRIAL ESTATE 20 BT63 5QD CRAIGAVON See on map Region Northern Ireland Northern Ireland Armagh City Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. CISBIO BIOASSAYS SAS France Net EU contribution € 0,00 Address PARC MARCEL BOITEUX 30200 CODOLET See on map Region Occitanie Languedoc-Roussillon Gard Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. EuroscreenSa Belgium Net EU contribution € 0,00 Address Rue Adrienne Bolland 6041 Gosselies See on map Region Région wallonne Prov. Hainaut Arr. Charleroi Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. 24 Media Labs Netherlands Net EU contribution € 0,00 Address Vasteland 78 3011 BN Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. VIVIA BIOSYSTMES S.L. Spain Net EU contribution € 0,00 Address MENENDEZ PELAYO ST 12 47001 VALLADOLID See on map Region Centro (ES) Castilla y León Valladolid Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data