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ONCOgenic Receptor Network of Excellence and Training

Objective

Cancer is a leading health concern. There is a need to fully understand the fundamental processes underlying development of cancer. There is increasing evidence that G protein-coupled receptors (GPCRs) and their associated signalling cascades are involved in both cancer progression and metastasis. As oncogenic GPCRs are likely to be amenable to manipulation via drugs they are ideal therapeutic targets. In ONCORNET (Oncogenic Receptor Network of Excellence and Training) we propose to target two oncogenic GPCRs; the chemokine receptors CXCR4 and CXCR7. These are highly expressed in a range of tumours and yet their role in cancer progression is not well understood. We will focus on unravelling how CXCR4 and CXCR7 are or can be modulated (small molecules, pepducins, nanodies) and investigate the effects on oncogenic responses. This represents crucial knowledge that we currently do not have and yet may well provide potential leads for drug development and commercialisation. ONCORNET will bring together the leading research scientists and labs in Europe with an interest in GPCRs and 15 early stage researchers. We will employ all the latest multidisciplinary research technologies to understand the role of these GPCRs in cancer and develop CXCR4 and CXCR7 tools for diagnostic and therapeutic purposes. Importantly, developed approaches can be extrapolated to other oncogenic GPCRs. The ONCORNET consortium will offer an extensive multidisciplinary training programme to the ESRs to ensure that they can operate in today’s drug discovery programmes. This will include both research (e.g. drug discovery, proteomics, imaging, modelling) and transferable (e.g. entrepreneurship, writing, media training) skill sets –that is rarely offered at PhD level. We will train ESRs to develop the next generation of multidisciplinary scientists with skills that are highly demanded by many of today’s employers in drug development industries.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer
  • /social sciences/economics and business/business and management/entrepreneurship
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

STICHTING VU
Address
De Boelelaan 1105
1081 HV Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 510 748,56

Participants (9)

THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 546 575,76
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 546 575,76
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany
EU contribution
€ 498 432,96
Address
Sanderring 2
97070 Wuerzburg
Activity type
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 525 751,20
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Participation ended

Germany
EU contribution
€ 0
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 512 091,89
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
UNIVERSIDAD AUTONOMA DE MADRID
Spain
EU contribution
€ 247 872,96
Address
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Activity type
Higher or Secondary Education Establishments
ARGEN-X
Belgium
EU contribution
€ 250 560
Address
Technologiepark 30
B-9052 Zwijnaarde
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GRIFFIN DISCOVERIES BV
Netherlands
EU contribution
€ 255 374,28
Address
De Boedelaan 1083
1081HV Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (6)

ACTELION PHARMACEUTICALS LTD
Switzerland
Address
Gewerbestrasse 16
4123 Allschwil
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ALMAC SCIENCES LIMITED
United Kingdom
Address
Almac House - Seagoe Industrial Estate 20
BT63 5QD Craigavon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Cisbio Bioassays
France
Address
Parc Marcel Boiteux
30200 Codolet
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Euroscreen S.A.
Belgium
Address
Rue Adrienne Bolland
6041 Gosselies
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
24 Media Labs
Netherlands
Address
Vasteland 78
3011 BN Rotterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Vivia Biosystmes S.L.
Spain
Address
Menendez Pelayo St 12
47001 Valladolid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)