Objective Ageing is the single most important factor in the onset of disease in the European population. An understanding of the molecular and physiological mechanisms that cause ageing is essential for the rational intervention of age-related disease. Simple model systems that exhibit ageing provide and economical means to obtain this understanding. We shall determine the genes and physiological mechanisms that cause ageing in Caenorhabditis elegant with a view to targeting processes that underlie age-associated disease in humans. This will be achieved by an extensive, interdisciplinary analysis of a series of genetic variants that exhibit greatly slowed rates of ageing resulting in life span control ageing rate and 300% (Age mutants). This analysis will reveal both regulatory mechanisms that control ageing rate and downstream mechanisms that constitute the molecular and physiological causes of ageing. We predict that many of the mechanisms we uncover will be universally linked to ageing in all animals and that consequently the targeting of these mechanisms will ameliorate age-related disease or postpone its onset. Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-6. - Key action The Ageing Population and Disabilities Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator GENT UNIVERSITY EU contribution No data Address K.L. Ledeganckstraat 35 9000 GENT Belgium See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all DEVGEN N.V. Belgium EU contribution No data Address 266,Technologiepark 9 9052 ZWIJNAARDE See on map Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germany EU contribution No data Address Ihnestrasse 73 14195 BERLIN See on map Total cost No data NATIONAL UNIVERSITY OF IRELAND - MAYNOOTH Ireland EU contribution No data Address 47 Maynooth - Co. Kildare See on map Total cost No data UNIVERSIDAD PABLO DE OLAVIDE Spain EU contribution No data Address Carretra de Utrera Km1 41013 SEVILLA See on map Total cost No data Birkbeck College, University of London United Kingdom EU contribution No data Address Malet Street, Bloomsbury WC1E 7HX London See on map Total cost No data