Objective
Ageing is the single most important factor in the onset of disease in the European population. An understanding of the molecular and physiological mechanisms that cause ageing is essential for the rational intervention of age-related disease. Simple model systems that exhibit ageing provide and economical means to obtain this understanding. We shall determine the genes and physiological mechanisms that cause ageing in Caenorhabditis elegant with a view to targeting processes that underlie age-associated disease in humans. This will be achieved by an extensive, interdisciplinary analysis of a series of genetic variants that exhibit greatly slowed rates of ageing resulting in life span control ageing rate and 300% (Age mutants). This analysis will reveal both regulatory mechanisms that control ageing rate and downstream mechanisms that constitute the molecular and physiological causes of ageing. We predict that many of the mechanisms we uncover will be universally linked to ageing in all animals and that consequently the targeting of these mechanisms will ameliorate age-related disease or postpone its onset.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
9000 GENT
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.