Objetivo The general aim of CAESAR is to produce (Q)SAR models for the prediction of the toxicity of chemical substances. These models will be designed to be used for regulatory purposes, more specifically to assist the implementation of the proposed REACH system. The project will develop predictive in silicon models for chemical toxicity. These modelling approaches will reduce the dependence on the use of animals as well as the costs associated with toxicity tests, and will have wide-ranging applications.The work will involve a robust and detailed characterisation of the most relevant endpoints as defined in EC documents relating to the requirements for REACH. Utmost attention will be paid to obtain a solid experimental basis by the use of toxicity data that have been checked for quality at all stages. At least 5 clearly defined data sets along with suitable statistical techniques will be exploited to form powerful, innovative and thoroughly validated (Q)SAR models. Models developed by each partner will be checked by at least one other partner. Each model will be characterised by its statistical uncertainty. The presence of false negative predictions will also be evaluated to reduce the risk of predicting potentially harmful compounds to be non-toxic. The applicability domain of each (Q)SAR will be described, both in terms of its boundaries and density in chemical and biological space. For each (Q)SAR, a detailed protocol will be prepared, describing the standardised models and the quality procedure adopted.The (Q)SAR models developed in this project, and their protocols, will be placed on the project's internet site to allow the widest possible free access. Further dissemination of the models will be through an international workshop at the end of the project. Exploitation will be achieved through the involvement of users and regulatory bodies. An external review committee will be formed to monitor the project progress and provide advice. Ámbito científico natural sciencescomputer and information sciencesinternetnatural sciencescomputer and information sciencesdatabasesnatural scienceschemical sciencesinorganic chemistrymetalloids Programa(s) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Tema(s) POLICIES-1.5 - Environmental assessment Convocatoria de propuestas FP6-2004-SSP-4 Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador ISTITUTO DI RICERCHE FARMACOLOGICHE "MARIO NEGRI" Aportación de la UE Sin datos Dirección VIA ERITREA 62 MILANO Italia Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (8) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo BIOCHEMICS CONSULTING SAS Francia Aportación de la UE Sin datos Dirección Centre d'Innovation - Rue Leonard de Vinci, 16 ORLEANS Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos CENTRAL SCIENCE LABORATORY Reino Unido Aportación de la UE Sin datos Dirección Nobel House 17 Smith Square LONDON Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos KEMIJSKI INSTITUT LJUBLJANA SLOVENIJA Eslovenia Aportación de la UE Sin datos Dirección Hajdrihova 19 LJUBLJANA Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos KNOWLEDGEMINER SOFTWARE FRANK LEMKE Alemania Aportación de la UE Sin datos Dirección Duererstr. 40 PANKETAL Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos LIVERPOOL JOHN MOORES UNIVERSITY Reino Unido Aportación de la UE Sin datos Dirección Mount Pleasant 70, Rodney House, Rodney Street 2 LIVERPOOL Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK - TNO Países Bajos Aportación de la UE Sin datos Dirección Schoemakerstaat 97 DELFT Ver en el mapa Coste total Sin datos POLITECNICO DI MILANO Italia Aportación de la UE Sin datos Dirección PIAZZA LEONARDO DA VINCI 32 20133 MILANO Ver en el mapa Coste total Sin datos UFZ - UMWELTFORSCHUNGSZENTRUM LEIPZIG-HALLE GMBH. Alemania Aportación de la UE Sin datos Dirección Permoser Strasse 15 LEIPZIG Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos