Conference in french: Research and development of bioartificial organs for cardiovascular diseases by Juan-Carlos CHACHQUES, MD, PhD
5 January 2015 - 5 January 2015
France
Place : Maison de l'AX, 5 rue Descartes, F-75005, Paris, France.
Date : January 5, 2015
Time : 17:00
Summary :
The basic and clinical cardiovascular research communities are developing and refining synergic therapies for epidemic chronic heart failure. Heart transplantation is an effective therapy for end-stage heart disease, but because of the shortage of donors, there is an increasing interest in more favourable alternatives like stem cell transplantation and tissue engineering for the creation of bioartificial organs and tissues. The ultimate translational goal is the development of biomechanical hearts.
Recent progress on the design and fabrication of bio-hybrid materials having biometric characteristics has been accomplished in the field of nanotechnology for direct applications in medicine and engineering. The main purpose of these materials is to create tissues and organs and display structural and functional properties similar to natural extracellular matrices, containing truly three-dimensional nano-structures and controlling the delivery and effective concentration of bioactive signals and cells. New technology emerges to create fully functional, bio-mechanical replacement hearts, including hemocompatible implantable prostheses connected to external electric power supply or pneumatic activation systems, asociated with remote monitoring and electronic control systems for the hospital operative follow-up and for home-monitoring.
References :
J.-C. Chachques and co-authors, Creating the bioartificial myocardium for cardiac repair : challenges and clinical targets, Expert Rev. Cardiovasc. Ther. 11(12), 1701--1711 (2013).
J.-C. Chachques and co-authors, Cardiac Bioassist : Results of the French Multicenter Cardiomyoplasty Study, Asian Cardiovasc. Thorac Ann 2009; 17; 573--580.
Date : January 5, 2015
Time : 17:00
Summary :
The basic and clinical cardiovascular research communities are developing and refining synergic therapies for epidemic chronic heart failure. Heart transplantation is an effective therapy for end-stage heart disease, but because of the shortage of donors, there is an increasing interest in more favourable alternatives like stem cell transplantation and tissue engineering for the creation of bioartificial organs and tissues. The ultimate translational goal is the development of biomechanical hearts.
Recent progress on the design and fabrication of bio-hybrid materials having biometric characteristics has been accomplished in the field of nanotechnology for direct applications in medicine and engineering. The main purpose of these materials is to create tissues and organs and display structural and functional properties similar to natural extracellular matrices, containing truly three-dimensional nano-structures and controlling the delivery and effective concentration of bioactive signals and cells. New technology emerges to create fully functional, bio-mechanical replacement hearts, including hemocompatible implantable prostheses connected to external electric power supply or pneumatic activation systems, asociated with remote monitoring and electronic control systems for the hospital operative follow-up and for home-monitoring.
References :
J.-C. Chachques and co-authors, Creating the bioartificial myocardium for cardiac repair : challenges and clinical targets, Expert Rev. Cardiovasc. Ther. 11(12), 1701--1711 (2013).
J.-C. Chachques and co-authors, Cardiac Bioassist : Results of the French Multicenter Cardiomyoplasty Study, Asian Cardiovasc. Thorac Ann 2009; 17; 573--580.