Neuronal structure and Dynamics, Brain plasticity
5 December 2016 - 5 December 2016
France
Abstract:
We have recently shown rapid cannabinoid-induced remodeling of the neuronal actomyosin cytoskeleton with potentially important roles in developmental brain wiring. Our recent results indicate a role for cannabinoid-induced actomyosin contraction also in synaptic plasticity. Completing our in vitro and ex vivo tools, we participate in the interdisciplinary development of a new in vivo imaging modality, functional fast brain ultrasound (fUS), to investigate the role of cannabinoid-induced actomyosin contraction in the structure and connectivity of the living rodent brain. fUS offers fMRI-like functional imaging, both in anaesthetised and awake animals, with spatio-temporal resolution gains of several orders of magnitude as compared to fMRI.
Recent relevant publications:
Renard et al. Eur Neuropsychopharmacol. 2016 Chatelin et al. Journal of Cerebral Blood Flow and Metabolism, 2016 Errico et al. Nature, 2015 Roland et al. eLife, 2014 Osmanski et al. Nature Communications, 2014
We have recently shown rapid cannabinoid-induced remodeling of the neuronal actomyosin cytoskeleton with potentially important roles in developmental brain wiring. Our recent results indicate a role for cannabinoid-induced actomyosin contraction also in synaptic plasticity. Completing our in vitro and ex vivo tools, we participate in the interdisciplinary development of a new in vivo imaging modality, functional fast brain ultrasound (fUS), to investigate the role of cannabinoid-induced actomyosin contraction in the structure and connectivity of the living rodent brain. fUS offers fMRI-like functional imaging, both in anaesthetised and awake animals, with spatio-temporal resolution gains of several orders of magnitude as compared to fMRI.
Recent relevant publications:
Renard et al. Eur Neuropsychopharmacol. 2016 Chatelin et al. Journal of Cerebral Blood Flow and Metabolism, 2016 Errico et al. Nature, 2015 Roland et al. eLife, 2014 Osmanski et al. Nature Communications, 2014
Keywords
Neuronal structure