'Ubiquitin and Autophagy', Amsterdam, the Netherlands
26 June 2013 - 26 June 2013
Netherlands
An event entitled 'Ubiquitin and Autophagy' will take place from 26 to 27 June 2013 in Amsterdam, the Netherlands.
Nothing lasts forever. Many proteins, in fact, do not last more than a few minutes. The human body cells are continually building proteins, using them for a single task, and then discarding them. Cells need to control the destruction of their own proteins, making sure that they remove only proteins that aren't needed any more. The small protein Ubiquitin plays a central role in this job. Ubiquitin is found in all eukaryotic cells and in cells throughout the body.
In the subsequent years, it has become apparent that apart from its role in protein disposal, ubiquitin is also used for other tasks, such as directing the transport of proteins in and out of the cell. By connecting ubiquitin together in short or long chains, or using different types of linkages between the molecules, many different signals may be encoded.
The event will bring together researchers from the fields of ubiquitin signaling as well as autophagy, a process that depends on the ubiquitin-like proteins Atg8 and Atg12. It is now clear that many mechanistic aspects and signalling concepts of ubiquitin attachment, recognition and hydrolysis are shared in the autophagy system. More importantly, significant cross-talk exists, as ubiquitination plays a central role in determining cargo for autophagosomal processing.
The conference will highlight the most recent developments in ubiquitin and autophagy research, and how the two fields can learn from each other.For further information, please visit
http://www.abcam.com/index.html?pageconfig=resource&rid=15264(opens in new window)
Nothing lasts forever. Many proteins, in fact, do not last more than a few minutes. The human body cells are continually building proteins, using them for a single task, and then discarding them. Cells need to control the destruction of their own proteins, making sure that they remove only proteins that aren't needed any more. The small protein Ubiquitin plays a central role in this job. Ubiquitin is found in all eukaryotic cells and in cells throughout the body.
In the subsequent years, it has become apparent that apart from its role in protein disposal, ubiquitin is also used for other tasks, such as directing the transport of proteins in and out of the cell. By connecting ubiquitin together in short or long chains, or using different types of linkages between the molecules, many different signals may be encoded.
The event will bring together researchers from the fields of ubiquitin signaling as well as autophagy, a process that depends on the ubiquitin-like proteins Atg8 and Atg12. It is now clear that many mechanistic aspects and signalling concepts of ubiquitin attachment, recognition and hydrolysis are shared in the autophagy system. More importantly, significant cross-talk exists, as ubiquitination plays a central role in determining cargo for autophagosomal processing.
The conference will highlight the most recent developments in ubiquitin and autophagy research, and how the two fields can learn from each other.For further information, please visit
http://www.abcam.com/index.html?pageconfig=resource&rid=15264(opens in new window)