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Next Generation of Nanoscopies in Biosciences - Seven EU-funded Initiatives presented approaches and results in a public workshop

Contributed by: FSRM Swiss Foundation for Research in Microtechnology

The EU-funded research project ChipScope has brought together seven EU-funded projects in a public workshop to present and discuss current topics on the next generation of nanoscopies in biosciences. The event took place on September 11, during the EUROSENSORS 2018 conference in Graz, Austria.
Next Generation of Nanoscopies in Biosciences - Seven EU-funded Initiatives presented approaches and results in a public workshop
The workshop has been initiated by the ChipScope project which aims to overcome the limits of diffraction with super-resolution lighting on a chip. It was chaired by Dr. Hutomo Suryo Wasisto from Technische Universität Braunschweig (Germany).

The ChipScope project was presented by Prof. J. Daniel Prades from University of Barcelona. Its aim: overcoming the Limits of Diffraction with Super-Resolution Lighting on a Chip. In ChipScope, the consortium will revolutionize optical microscopes with super-resolution capabilities, making them chip-sized, convenient, affordable and ubiquitously available, not only for laboratories working in manifold research fields, but also in everyday life. During the project, very small nanoLEDs of below Abbe limits in size (this is 1000 times smaller than the diameter of a human hair) will be developed and used as light sources for a new microscope, which will be integrated on a chip. The fundamental difference with conventional optical microscopy will be that the illumination is made by extremely small individual light sources instead of a wide illumination field and tiny detectors in the camera. This allows super-resolution (< 50 nm) optical microscopy, which could be used to investigate extremely small structures as viruses, DNA or living cells, in real time. (More information: http://www.chipscope.eu/)

The AdOMiS project was presented by Prof. Dr. Martin Booth from University of Oxford (UK). Its aim is adaptive optical microscopy systems which can instantly react to and compensate fluctuations while scanning the specimen. (More information: https://cordis.europa.eu/project/rcn/204867_en.html)

The Chromavision project was presented by Prof. Dr. Erwin Peterman from Vrije Universiteit Amsterdam. It develops a novel technique to do chromosome imaging and manipulation. The platform will allow molecular biologists to automatically isolate individual chromosomes from small tissue or cell samples and have these delivered to a super-resolution imaging system (i.e., the Super-Resolution Correlative Tweezers Fluorescence Microscope (CTFM-SR3D)). (More information: http://chromavision.eu/)

The MolMap project is led by Prof. Dr. Ralf Jungmann from Ludwig-Maximillians Universität München (LMU) and Max-Planck-Institute (MPI) of Biochemistry. Its aim is to localize and identify arbitrary biomolecules (i.e., proteins, nucleic acids) and their cellular interactions in a complex tissue microenvironment with high multiplexity (hundreds of targets simultaneously) and ultra-resolution beyond the diffraction limit (< 5 nm). (More information: https://cordis.europa.eu/project/rcn/200542_en.html)

Prof. Dr. Wolfgang Drexler, head of the Drexler Lab at the Medical University Vienna, gave an introduction to the OCTChip project. The OCTChip program develops miniaturized and cost-reduced optical coherence tomography (OCT) devices especially for clinical praxis of eye care (ophthalmology). The project proposes the use of photonic integrated circuits (PICs) to reduce both the size and the cost of ophthalmic OCT systems significantly. (More information: http://www.octchip.researchproject.at/)

Prof. Dr. Marta Fajardo from University of Lisbon introduced the VOXEL project (volumetric medical x-ray imaging at extremely low dose). (More information: https://www.ipfn.tecnico.ulisboa.pt/voxel)

Dr. Peter Gnauck from Carl Zeiss Microscopy GmbH presented the npSCOPE project which will develop an instrument that couples the extraordinarily high resolution of the recently commercialised helium-ion microscope with sensors for composition (a mass spectrometer) and 3D visualisation (transmitted ion detector). The aim is to more fully characterise individual nanoparticles and their interaction with their biological environments (water, soil, body fluid, human cells and tissue, etc.) and to better understand the risks they might pose to human health or the environment. (More information: http://www.npscope.eu/)

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    Switzerland
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  • Austria, Switzerland, Germany, Spain, Italy, Netherlands, Portugal, United Kingdom

Keywords

superresolution, microscopy, adaptive optical microscopy, chromosome imaging and manipulation, cells, tissues, DNA origami, optical coherence tomography, photonic integrated circuits, chip-based ophthalmic OCT system, Computerized Tomography, 3D X-ray imaging, 3D medical imaging, physicochemical characterisation of nanoparticles, Nanoscopies in Biosciences, nanomedicine
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