A COMPREHENSIVE ‘PAEDIATRIC PRECLINICAL POC PLATFORM’ TO ENABLE CLINICAL MOLECULE DEVELOPMENT FOR CHILDREN WITH CANCER Build a comprehensive translational network of PDX models, matching cell lines/organoids and genetically modified mouse models with complete molecular characterization and proven relevance to major solid paediatric tumours. Paediatric cancer:20% of all paediatric cancer remains incurableLong term side effects associated with treatmentCancer is often much more advanced, i.e. metastatic, in children then adultsEffective and safe treatments are urgently needed Increasing the number of cures across a wide range of paediatric cancer histologies (more lives saved);Potentially mitigating the long term health effects typically associated with conventional chemotherapeutic, better quality of life