Objective
"The specification of the epidermis, or outer cell-layer of the plant occurs very early in embryogenesis. ADEK1 encodes a function absolutely required for early embryogenesis, and this function is likely to be a key component of the outer cell-layer speci fication pathway. Preliminary analysis of adek1 null alleles showed that they cause early embryo lethality involving serious cellular disorganisation and loss of epidermal marker expression in Arabidopsis. In addition, RNAi knock-downs of ADEK1 result in a severe phenotype characterised by loss of apical meristem organisation and function, and replacement of epidermal cells with mesophyll cells over most of the cotyledon surface. ADEK1 is predicted to encode a large membrane-localised protein with a C-ter minal region containing a calpain domain that could act in the cytosol to cleave specific target proteins. This project aims to place ADEK1 within its molecular context, both in relation to proteins with which it interacts, and with respect to its substra tes. We aim to characterise the functional requirements for the different domains of ADEK1 using a complementation approach. Yeast-two-hybrid screens will be performed to isolate potential interactors with ADEK1 of two classes; A) those which could act as regulators or facilitators of ADEK1 function and B) potential proteolytic substrates. The proposed project addresses the molecular basis of signalling, potentially both at the inter- and intracellular levels, responsible for the specification of epidermal cell identity."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.