Objective
To complete and diversify her scientific expertise, Dr. Ianari has decided to join Dr. Lees' lab, a leading lab located in a top-level research organization (MIT¿ USA). The aim of her project is to study the role of E2F1 acetylation in the DNA damage response and in the development and homeostasis of the normal tissues. E2F1 is a transcriptional factor that possess both oncogenic and tumour suppressive functions. The spectrum of E2F1-regulated genes is quite large and comprises genes involved in the regulation of development, differentiation, cell cycle progression and apoptosis. Dr. Ianari has recently demonstrated that DNA damage specifically activates E2F1 apoptotic potential in an acetylation-dependent manner by the selective relocalization of transcriptionally active E2F1 from cell cycle genes to the promoter of the proapoptotic p73 gene. Indeed, E2F1 acetylation is the main determinant of the outcome of E2F1 activity in response to DNA damage. Whether this pathway is specifically restricted to maintain tissue homeostasis in the presence of unrepairable DNA damage, or is involved in additional cell regulatory functions, is presently unknown.
The aim of this project is to use a gene targeting approach to generate a mouse strain that produces a version of E 2F1 that cannot be acetylated but is otherwise regulated physiologically. Dr. Ianari will combine highly innovative and sophisticated techniques (knock-in mouse model generation, chromatin immuno-precipitation and micro-array analysis) and multidisciplinary approaches (developmental biology, molecular biology and experimental oncology), to provide insight into the underlying mechanisms of tumour development that will aid the development of new selective cancer therapies. This experience will advance Dr. Ianari' s independent career development in two ways: she will gain additional knowledge both in scientific and technological terms, and it will provide her with long-lasting scientific collaborations.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
ROME
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.