Objective
The proposed research will develop a single device integrated micro system for nucleic acid extraction, mixing steps, purification, PCR amplification, biochemical reactions from biological samples e.g. blood, amplification, and DNA micro array detection in real time. The technologies that will be combined are silicon-based for the implementation of the detection and polymer-based for the micro fluidic part. The chip that will be developed in the project it will be ideally suited for being integrated in a portable low cost system that will perform the signal transduction, interpretation and data analysis.
The above described modules will be integrated within a single device where samples will be transported within and between modules via an enclosed micro fluidic channels system. The whole system will be interfaced by dedicated software that will be developed to make feasible and efficient the operation of the portable apparatus by general practitioners "packaged" as a portable automated functional system. The aim will be to deliver a product targeting low to medium throughput, low cost, point-of-care applications, with emphasis on providing very rapid and accurate results. The micro system that will be incorporated in the current research proposal will be modular, versatile, fully automated, requiring a minimum quantity of reagents and nucleic acid probes and reduced times for analysis.
Low density micro arrays will be printed accurately using a patented laser technique. Detection will be carried out by two alternative approaches, the photosensing and the capacitive, both implemented on the silicon device part. Both will be compared with an enhanced photographic method Micro heaters, temperature sensors, micro mixers will be also integrated into the micro system to enable good control of experiments and good reproducibility of hybridization results. The micro system that will be developed it will be validated for four different healthcare applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences data science
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- natural sciences biological sciences genetics DNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
19002 PEANIA
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.