Objective
A contrast agent is any substance able to enhance the information contained in an image derived from a medical diagnostic instrumentation concerning the traditional or digital radiology entailing the magnetic resonance, nuclear medicine, and last but not least ultrasound. The contrast agents can be administered orally or injected in the systemic circulation. Ultrasound contrast agents (UCAs) consist in dispersions of microbubbles containing air or other gases that can reflect efficiently ultrasound waves during an echo-tomographic investigation.
S.I.G.H.T. "Systems for in-situ theranostics using micro-particles triggered by ultrasound", is a project focused on the design of multifunctional UCAs as supporting devices for theranostics, i.e. for both diagnostic and therapeutic treatments, delivering drug to the right place in the body, in pathologies as thrombosis, tissue repearing and cancer therapies. The research activities of the project will concern the formulation of the devices (microballoons and microcapsules), their ultrasound and mechanical properties, tagging of the device outer surface with specific molecules for a target tissue or organ, bioadhesion and biocompatibility tests, drug release properties of the devices upon insonification of coronary artery smooth muscle, endothelial cells, clots (sonothrombolysis), hepatocellular carcinoma and colon cancer cells. Image processing and reconstruction derived from the ultrasound devices will be carried out with the design of ad hoc hardware and software.
Exploitation of microballoons and microcapsules in ex situ applications will be also tackled by formulating self - assembled microarrays for high throughput analysis. A dissemination and exploitation activity will be carried out with the final release of a prototype acting on a mimicking phantom of an organ and with the supporting know-how for "next step" actions as validation plan and pre-competitive industrialization.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine radiology nuclear medicine
- medical and health sciences clinical medicine oncology colorectal cancer
- medical and health sciences basic medicine pathology
- natural sciences physical sciences acoustics ultrasound
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00131 ROMA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.