Objective
COCHISE is the first step of an activity aimed at the development of enabling micro-technologies to monitor physiological cellular interactions at the single cell level with a high throughput. It will be applied first to the immunological monitoring of anti-tumour vaccinations, singling out the rare effector cells (in the order of 10-3) that are actually active against tumour cells. The sensor that we are developing consists of an orderly matrix of about 4,000 living cells deposited in microwells created in a biocompatible substrate that also serves as a high-density circuit board.
The microwells are monitored by an external microscope and have an embedded addressable impedance sensor. The key point is that each microwell can force contact between individual cells, and detect consequences of these contacts. The project integrates on the same platform several technologies such as electronic sensing, microfluidic interfaces for cell dispensing, control of osmotic balance of nutrients, management of evaporation, surface nano-modifications for management of fluid flows (e.g. hydrophilic and/or hydrophobic surface tend to drive or repel droplets) and avoidance or induction of surface cell adhesion. At the system level, cell delivery will leverage recent results that allow to delivery single cells in an effective way.
An important side of the research is the definition of new therapeutic and diagnostic protocols for the immunotherapy of cancer. As a first step, we will apply our technology to the analysis of anti-tumour lytic effector cells, for a precise quantification of how many lytic events happen in the array, their locations and timings. A major advantage is that the cells are kept alive and can be retrieved individually for further analysis, such as gene expression profiling.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors biosensors
- natural sciences biological sciences cell biology
- natural sciences biological sciences genetics RNA transcriptomes
- medical and health sciences basic medicine immunology immunotherapy
- engineering and technology other engineering and technologies microtechnology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BOLOGNA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.