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Content archived on 2024-06-16

Hybrid Integrated BIophotonic Sensors Created by Ultrafast laser Systems

Project description


Photonic components

A biochip is a device that squeezes the functionalities of a biological laboratory on a single substrate through a network of microfluidic channels, reservoirs, valves, pumps and micro-sensors. Its advantages are high sensitivity, speed of analysis, low sample consumption and measurement automation and standardization. This concept promises dramatic advances both in basic research and in clinical applications as a low-cost diagnostic tool.We propose the demonstration of a new technology, based on high intensity femtosecond laser pulses, providing an integrated platform for the fabrication of biochips with photonic functionalities. Such technology enables to include a network of femtosecond written optical waveguides on a standard biochip. The waveguides can be arranged in different configurations with respect to the microfluidic channels, exploiting the unique three-dimensional capabilities of the femtosecond writing technique, to implement photonic biosensors.An additional goal is the use of the femtosecond laser technology to directly write the microfluidic channels. If both goals are achieved, we can envisage a single production machine for the biophotonic chips, based on a high-power femtosecond laser, that can manufacture both the microfluidic channels and the optical waveguides.To achieve these goals we will demonstrate advanced diode-pumped femtosecond laser sources, with average power higher than currently available. These laser sources need to be sufficiently compact, reliable and user-friendly for industrial environment.The unique integration of photonics and microfluidics, enabled by the inscription of optical waveguides on the biochips, will allow to implement a wealth of novel biosensing functionalities. We concentrate on two prototypical devices, available as demonstrators at the end of the project: microreactors for chemical synthesis of polypeptides and proteins, and biomolecule assays based on capillary electrophoresis.

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Topic(s)

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Call for proposal

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FP6-2005-IST-5
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Funding Scheme

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STREP - Specific Targeted Research Project

Coordinator

POLITECNICO DI MILANO
EU contribution
€ 464 400,00
Address
Piazza L. da Vinci 32
20133 Milano
Italy

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Activity type
Higher or Secondary Education Establishments
Total cost

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Participants (7)

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