Objective
Cardiovascular disease is the biggest cause of morbidity and mortality in Europe. Its study brings together experts from the physical and life sciences with clinical practitioners in the search for understanding of the complex processes underpinning cardio vascular physiology. This proposal seeks to develop an energetically consistent framework into which models of disparate processes on disparate time and length scales can be integrated to further this understanding. It would be unrealistic to expect this programme to pull together all multidisciplinary threads, but it can develop a coherent framework for cardiovascular simulation. It will focus on the integration of bond graph elements, representing system characteristics in a coherent and intuitive manner, with 3D computational models, providing detail of local stress distributions and flow structures. The bond graph framework offers the facility for ready and consistent integration of descriptors of mechanical, chemical, electrical and biological events.
The simulation environment will be exercised in the study of an important problem in cardiovascular mechanics, namely the evaluation of closure forces of heart valve prostheses. For mechanical heart valve prostheses these can be very high, and can lead to early failure and, in some cases, to local cavitation in the blood. There are currently no models that integrate the mechano-chemical characteristics of the ventricular wall with local haemodynamics to compute closure forces. All current sophisticated models (including fluid-solid interaction) require explicit definition of either ventricular motion or pressure. The success of this proposal hinges on the combination of the expertise of the applicant, in bond graph modelling, with that of the host institution , in finite element analysis, computational fluid dynamics and in computational simulation environment development. The host department is located in a teaching hospital and has major clinical collaborations.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences software
- natural sciences biological sciences biophysics
- natural sciences physical sciences classical mechanics fluid mechanics fluid dynamics computational fluid dynamics
- natural sciences computer and information sciences computational science multiphysics
- medical and health sciences medical biotechnology implants
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SHEFFIELD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.