Objective The signalling molecule encoded by the wingless (wg) gene (the fruit-fly homologue of the mammalian proto-oncogene Wnt-1) elicits distinct responses in different tissues during the development of the fruit fly Drosophila melanogaster. In particular, wg is required for the proliferation of the hinge cells (which will give rise to the structures joining the wing to the trunk of the fly), and its over-expression leads to the over-proliferation of the hinge cells.In this project we aim at:(1) to define the specific cell cycle properties of hinge cells that might be related to this proliferative response, and to study their control by wg;(2) to identify genes that are controlled by wg and which mediate the induction of cell proliferation; and(3) to determine fact ors that condition hinge cells to proliferate upon wg stimulation and how these factors relate to cell cycle control.These results might serve as a basis, first, to understand how Wnt signals regulate proliferation during normal development, second, to throw light on the general phenomenon of developmental specificity of intercellular signalling pathways, and third to understand why tumour induction by mutations in the Wnt signalling pathway is tissue-specific. Fields of science natural sciencesbiological sciencesgeneticsmutation Keywords Cell cycle control during development animal model for cancer research Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Call for proposal FP6-2002-MOBILITY-5 See other projects for this call Funding Scheme EIF - Marie Curie actions-Intra-European Fellowships Coordinator UNIVERSIDAD PABLO DE OLAVIDE - CENTRO ANDALUZ DE BIOLOGÍA DEL DESAROLLO EU contribution No data Address Ctra de Utrera, km 1 SEVILLA Spain See on map Links Website Opens in new window Total cost No data
