Objective
The signalling molecule encoded by the wingless (wg) gene (the fruit-fly homologue of the mammalian proto-oncogene Wnt-1) elicits distinct responses in different tissues during the development of the fruit fly Drosophila melanogaster. In particular, wg is required for the proliferation of the hinge cells (which will give rise to the structures joining the wing to the trunk of the fly), and its over-expression leads to the over-proliferation of the hinge cells.
In this project we aim at:
(1) to define the specific cell cycle properties of hinge cells that might be related to this proliferative response, and to study their control by wg;
(2) to identify genes that are controlled by wg and which mediate the induction of cell proliferation; and
(3) to determine fact ors that condition hinge cells to proliferate upon wg stimulation and how these factors relate to cell cycle control.
These results might serve as a basis, first, to understand how Wnt signals regulate proliferation during normal development, second, to throw light on the general phenomenon of developmental specificity of intercellular signalling pathways, and third to understand why tumour induction by mutations in the Wnt signalling pathway is tissue-specific.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SEVILLA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.