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Understanding microbiomes of the ruminant holobiont

Objective

Sustainability of ruminant production is of concern to society because of its implications for the environment, the economy and food security. Microbiomes associated with the host play a key role in health, welfare and environmental efficiency in ruminant production systems. However, despite the information already available, we lack the insights to precisely link the causes and mechanisms of microbial influence on ruminant phenotypes. This is because the interconnection and communication between the animal and its different microbiomes have never been studied in a deep, integrated way.
The goal of the project is to elucidate the role of ruminant-associated microbiomes and their interplay with the host in early life and throughout fundamental life events. HoloRuminant will use a holistic multi-omics approach to characterise the acquisition and evolution of microbiomes from different body sites, their inheritability and their influence on the host’s resistance to disease and environmental efficiency of production. Specifically we will: determine microbiomes’ functions by combining multi-level information for microbes, host and their interaction; define microbiomes’ roles during challenging life periods such as perinatal, weaning, and after exposure to pathogens; and evaluate the effect of ruminant microbiomes on critical phenotypes for sustainable production, health and welfare. This will allow the identification of novel microbial markers for monitoring, predicting and selecting phenotypes of interest. By engaging actors from the livestock value chain, we will evaluate the socio-economic impact and acceptability of the innovations proposed among stakeholders and the public.
HoloRuminant will provide highly innovative, standardized methodologies that will radically advance our understanding of the ruminant holobiont. This knowledge and the tools created will allow the use of microbiome-based diagnostics and solutions for improving ruminant sustainabilty.

Call for proposal

H2020-SFS-2020-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
Address
147 Rue De L'universite
75007 Paris Cedex 07
France
Activity type
Research Organisations
EU contribution
€ 1 240 470

Participants (24)

AARHUS UNIVERSITET
Denmark
EU contribution
€ 100 035,75
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
AGRESEARCH LIMITED
New Zealand
EU contribution
€ 0
Address
East Street
3240 Hamilton
Activity type
Research Organisations
AGRIFOOD AND BIOSCIENCES INSTITUTE
United Kingdom
EU contribution
€ 179 908,75
Address
Newforge Lane 18A
BT9 5PX Belfast
Activity type
Research Organisations
THE AGRICULTURAL RESEARCH ORGANISATION OF ISRAEL - THE VOLCANI CENTRE
Israel
EU contribution
€ 296 250
Address
Derech Hamcabim 68
50250 Bet Dagan
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
BEN-GURION UNIVERSITY OF THE NEGEV
Israel
EU contribution
€ 650 000
Address
.
84105 Beer Sheva
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 626 261,25
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
Australia
EU contribution
€ 0
Address
Clunies Ross Street Csiro Black Mountain Science And Innovation Park
2601 Acton Act
Activity type
Research Organisations
FEDERAZIONE EUROPEA DI ZOOTECNICA
Italy
EU contribution
€ 176 300
Address
Via Giuseppe Tomassetti 3 A/1
00161 Roma
Activity type
Other
EUROPEAN FORUM OF FARM ANIMAL BREEDERS
Netherlands
EU contribution
€ 278 625
Address
Silkeborg 75
2905 AT Capelle Aan Den Ijssel
Activity type
Research Organisations
INSTITUT DE L'ELEVAGE
France
EU contribution
€ 112 856,25
Address
Rue De Bercy 149
75012 Paris
Activity type
Research Organisations
INSTITUT DE RECERCA I TECNOLOGIA AGROALIMENTARIES
Spain
EU contribution
€ 101 475
Address
Ctra C-59 Km 12 Torre Marimon
08140 Caldes De Montbui Barcelona
Activity type
Other
INRAE TRANSFERT SAS
France
EU contribution
€ 400 000
Address
Rue Du Docteur Finlay 28
75015 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LUONNONVARAKESKUS
Finland
EU contribution
€ 688 400
Address
Latokartanonkaari 9
00790 Helsinki
Activity type
Research Organisations
LIETUVOS SVEIKATOS MOKSLU UNIVERSITETAS
Lithuania
EU contribution
€ 219 335
Address
A Mickeviciaus Gatve 9
44307 Kaunas
Activity type
Higher or Secondary Education Establishments
NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET
Norway
EU contribution
€ 620 560
Address
Universitetstunet 3
1433 As
Activity type
Higher or Secondary Education Establishments
NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
EU contribution
€ 195 706,25
Address
University Road
H91 Galway
Activity type
Higher or Secondary Education Establishments
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
EU contribution
€ 953 126
Address
University Road Lanyon Building
BT7 1NN Belfast
Activity type
Higher or Secondary Education Establishments
SRUC
United Kingdom
EU contribution
€ 759 957,50
Address
West Mains Road
EH9 3JG Edinburgh
Activity type
Higher or Secondary Education Establishments
TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY
Ireland
EU contribution
€ 1 023 093
Address
Oak Park
R93 Carlow
Activity type
Higher or Secondary Education Establishments
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
Canada
EU contribution
€ 0
Address
1-560 Enterprise Square 10230 Jasper Avenue Research Services Office
T5J 4P6 Edmonton Alberta
Activity type
Higher or Secondary Education Establishments
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
EU contribution
€ 0
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT GENT
Belgium
EU contribution
€ 250 937
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET GREIFSWALD
Germany
EU contribution
€ 346 250
Address
Domstrasse 11
17489 Greifswald
Activity type
Higher or Secondary Education Establishments
WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 505 217
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments