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HARNESSING THE POWER OF NATURE THROUGH PRODUCTIVE MICROBIAL CONSORTIA IN BIOTECHNOLOGY – MEASURE, MODEL, MASTER

Objective

The deliberate control of complex microbiomes is notoriously difficult and current approaches are often guided by simple trial-and-error. Advances in quantitative analysis modelling and design of these systems are urgently needed to improve the predictability and enable exploitation of the amazing synthesis capacities of microbiomes. The PROMICON project will learn from nature how microbiomes function through development and application of quantitative physiology, imaging, cell sorting machine learning and systems biology. This will be used to steer existing microbiomes towards production and to generate new synthetic microbiomes inspired by nature through an iterative design-build-test-learn cycle. The new consortia will also contain strains developed through systems metabolic engineering and will be used for the production of energy carriers, drop-in chemical feedstocks and advanced biomaterials.
PROMICON will advance characterization tools to understand which strains (modules) are needed for a successful microbiome. It will identify the primary producers (farmers), secondary converters (labourers) and essential strains for microbiome stability (balancers). This knowledge will be used to reduce complexity of natural microbiomes for optimized production of phycobilli protein based pigments, exo-polysaccharides (EPS) and poly-hydroxyalkanoates (PHA) in a top-down approach. Secondly, synthetic microbiomes with increasing complexity (bottom-up) will be assembled for the production of butanol, H2 and PHACOS, a functionalized antimicrobial polyester. PROMICON will develop new reactor concepts and downstream processing for microbiomes and conduct early-stage life cycle assessment (LCA) to prepare exploitation.
This ground-breaking project will not only inspire completely new production pathways and a paradigm shift from monocultures to mixed cultures in biotechnology, but also has the potential beyond biotechnology to inspire novel treatment options in biomedicine.

Call for proposal

H2020-FNR-2020-2
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Funding Scheme

RIA - Research and Innovation action

Coordinator

HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ
Address
Permoserstrasse 15
04318 Leipzig
Germany
Activity type
Other
EU contribution
€ 1 274 525

Participants (9)

UPPSALA UNIVERSITET
Sweden
EU contribution
€ 426 687,50
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
NOVA ID FCT - ASSOCIACAO PARA A INOVACAO E DESENVOLVIMENTO DA FCT
Portugal
EU contribution
€ 838 750
Address
Campus De Caparica Faculdade De Ciencias E Tecnologia Da Universidade Nova De Lisboa
2829 516 Caparica
Activity type
Research Organisations
UNIVERSITAT POLITECNICA DE CATALUNYA
Spain
EU contribution
€ 440 375
Address
Calle Jordi Girona 31
08034 Barcelona
Activity type
Higher or Secondary Education Establishments
ASOCIACION DE INVESTIGACION METALURGICA DEL NOROESTE
Spain
EU contribution
€ 493 750
Address
Calle Relva Torneiros 27A
36410 Porrino
Activity type
Research Organisations
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 974 375
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
PENSOFT PUBLISHERS
Bulgaria
EU contribution
€ 253 750
Address
Ul. Geo Milev 13A
1111 Sofia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ONCYT MICROBIOLOGY AG
Switzerland
EU contribution
€ 312 500
Address
Marchwartstrasse 61
8038 Zurich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ISLE UTILITIES BV
Netherlands
EU contribution
€ 435 000
Address
Cruquiusweg 1
2102 LS Heemstede
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOPOLIS SL
Spain
EU contribution
€ 550 000
Address
Calle Catedratico Agustin Escardino 9
46980 Paterna Valencia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)