Dynamic ubiquitin signalling coordinates transcriptional reprogramming in plant immunity

Project description

Harnessing ubiquitin signalling to boost plant protection

Dynamic regulation of gene expression is vital for all organisms and enables them to respond to the ever-changing environment. In response to pathogen attacks, plant cells display dramatic reprogramming of the transcriptome. The EU-funded UbRegulate project will explore the role of the immunising hormone salicylic acid (SA) in this process. SA employs the small post-translational modifier ubiquitin to establish durable immunity. It also induces dynamic modification of regulatory proteins with ubiquitin chains of diverse linkage types, generating the potential to control their functions and activities. The project aims to reveal how SA-induced ubiquitin signalling engages the transcriptional machinery and explore how this may be exploited by agrichemical biology.

Fields of science

• medical and health sciences › basic medicine › immunology
• medical and health sciences › health sciences › nutrition
• agricultural sciences › agriculture, forestry, and fisheries › agriculture › agronomy › plant protection
• natural sciences › biological sciences › biochemistry › biomolecules › proteins

Programme(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)

Topic(s)

• ERC-2020-COG - ERC CONSOLIDATOR GRANTS

Call for proposal

ERC-2020-COG
See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

THE UNIVERSITY OF EDINBURGH

Address

Old College, South Bridge
EH8 9YL Edinburgh
United Kingdom

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 2 000 000

Beneficiaries (1)

THE UNIVERSITY OF EDINBURGH

United Kingdom

EU contribution

€ 2 000 000

Address

Old College, South Bridge
EH8 9YL Edinburgh

Activity type

Higher or Secondary Education Establishments