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EXaSCale smArt pLatform Against paThogEns for Corona Virus

Project description

Computer-aided design of COVID-19 drugs

Advanced computer-aided drug design (CADD) has come to revolutionise drug discovery, and in combination with high-throughput biochemical and phenotypic screening, it allows the rapid evaluation of new drugs. Scientists of the EU-funded EXSCALATE4CoV project will employ the EXSCALATE platform containing the most promising commercialised drugs safe in man, to identify specific inhibitors against COVID-19. The strategy entails the computational alignment of these drugs against 3D models for the viral proteins, followed by biochemical assays and phenotypic screening of the most promising candidates. Molecules capable of blocking virus replication will be forwarded for development and registration.

Field of science

  • /medical and health sciences/health sciences/infectious disease/RNA virus/coronavirus

Call for proposal

H2020-SC1-PHE-CORONAVIRUS-2020
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

DOMPE FARMACEUTICI SPA
Address
Via S Martino Della Battaglia 12
20122 Milano
Italy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 409 375

Participants (17)

CINECA CONSORZIO INTERUNIVERSITARIO
Italy
EU contribution
€ 96 250
Address
Via Magnanelli 6/3
40033 Casalecchio Di Reno Bo
Activity type
Research Organisations
POLITECNICO DI MILANO
Italy
EU contribution
€ 141 250
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 96 250
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 126 250
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY
Poland
EU contribution
€ 70 625
Address
Ks. Trojdena 4
02-109 Warsaw
Activity type
Research Organisations
ELETTRA - SINCROTRONE TRIESTE SCPA
Italy
EU contribution
€ 287 250
Address
Ss 14 Km 163.5 Area Science Park
34149 Basovizza Trieste
Activity type
Research Organisations
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 386 000
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION
Spain
EU contribution
€ 232 375
Address
Calle Jordi Girona 31
08034 Barcelona
Activity type
Research Organisations
FORSCHUNGSZENTRUM JULICH GMBH
Germany
EU contribution
€ 96 250
Address
Wilhelm Johnen Strasse
52428 Julich
Activity type
Research Organisations
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy
EU contribution
€ 127 500
Address
Corso Umberto I, 40
80138 Napoli
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI CAGLIARI
Italy
EU contribution
€ 188 750
Address
Via Universita 40
09124 Cagliari
Activity type
Higher or Secondary Education Establishments
SIB INSTITUT SUISSE DE BIOINFORMATIQUE
Switzerland
EU contribution
€ 277 750
Address
Rue Michel Servet 1 Cmu
1206 Geneve
Activity type
Research Organisations
KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 96 250
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
EU contribution
€ 116 250
Address
Via Portuense, 292
00149 Roma
Activity type
Research Organisations
ASSOCIAZIONE BIG DATA
Italy
EU contribution
€ 96 250
Address
Via Piero Gobetti, 101
40129 Bologna
Activity type
Other
ISTITUTO NAZIONALE DI FISICA NUCLEARE
Italy
EU contribution
€ 41 250
Address
Via Enrico Fermi 54
00044 Frascati
Activity type
Research Organisations
CHELONIA SA
Switzerland
EU contribution
€ 85 000
Address
Piazzetta San Carlo 2
6901 Lugano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)