Computer-aided design of COVID-19 drugs
Advanced computer-aided drug design (CADD) has come to revolutionise drug discovery, and in combination with high-throughput biochemical and phenotypic screening, it allows the rapid evaluation of new drugs. Scientists of the EU-funded EXSCALATE4CoV project will employ the EXSCALATE platform containing the most promising commercialised drugs safe in man, to identify specific inhibitors against COVID-19. The strategy entails the computational alignment of these drugs against 3D models for the viral proteins, followed by biochemical assays and phenotypic screening of the most promising candidates. Molecules capable of blocking virus replication will be forwarded for development and registration.
Field of science
- /medical and health sciences/health sciences/infectious disease/RNA virus/coronavirus
Call for proposal
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Funding SchemeRIA - Research and Innovation action