Evaluation of a production ready portable, Point-of-Need Platform (instrument and reagents), direct from nasal swab test for the molecular diagnostic detection of COVID-19 infection.

Project Information

KRONO

Grant agreement ID: 101005075

DOI 10.3030/101005075

Project closed

EC signature date 30 September 2020

Start date 1 September 2020

End date 30 June 2022

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 1 819 963,75

EU contribution € 784 470,00

Coordinated by

UNIVERSITE D'AIX MARSEILLE
France

Deliverables

Documents, reports (7)

IMI2 reports
SARS-CoV-2 lysis and detection data and swab eluate testing

SARSCoV2 lysis and detection data and swab eluate testing

Report covering performance of the full assay from a frozen reagent
Definition of the areas of collaboration potential synergies with grants awarded under the Call IMI2-2020-21-01

Definition of the areas of collaboration potential synergies with grants awarded under the Call IMI220202101

Approval of the study by the Local Ethical Committees
Report and data set covering the performance evaluation
Validation data for the performance of the lyophilised Disease X assay.

D54 Validation data for the performance of the lyophilised Disease X assay

Demonstrators, pilots, prototypes (1)

Quantified standard for performance evaluation of SARS-CoV-2 assays

Quantified standard for performance evaluation of SARSCoV2 assays

Open Research Data Pilot (1)

Data Management Plan

Publication and dissemination of project data

Publications

Peer reviewed articles (6)

COVID-19 Rapid Antigen Test as Screening Strategy at Points of Entry: Experience in Lazio Region, Central Italy, August–October 2020

Author(s): Colavita F, Vairo F, Meschi S, Valli MB, Lalle E, Castilletti C, Fusco D, Spiga G, Bartoletti P, Ursino S, Sanguinetti M, Di Caro A, Vaia F, Ippolito G, Capobianchi MR.
Published in: Biomolecules, 2021, ISSN 0000-0000
Publisher: Biomolecules
DOI: 10.3390/biom11030425

16S rRNA gene sequencing of rectal swab in patients affected by COVID-19

Author(s): Mazzarelli A, Giancola ML, Farina A, Marchioni L, Rueca M, Gruber CEM, Bartolini B, Bartoli TA, Maffongelli G, Capobianchi MR, Ippolito G, Di Caro A, Nicastri E, Pazienza V, INMI COVID-19 study group
Published in: Plos One, 2021, ISSN 0000-0000
Publisher: Jane Foster, McMaster University, CANADA
DOI: 10.1371/journal.pone.0247041

Saliva Is a Valid Alternative to Nasopharyngeal Swab in Chemiluminescence-Based Assay for Detection of SARS-CoV-2 Antigen

Author(s): Amendola A, Sberna G, Lalle E, Colavita F, Castilletti C, Menchinelli G, Posteraro B, Sanguinetti M, Ippolito G, Bordi L, Capobianchi MR, On Behalf Of Inmi Covid-Study Group.
Published in: Journal of Clinical Medecine, 2021, ISSN 0000-0000
Publisher: Journal of Clinical Medecine
DOI: 10.3390/jcm10071471

Investigation of Nasal/Oropharyngeal Microbial Community of COVID-19 Patients by 16S rDNA Sequencing

Author(s): Rueca M, Fontana A, Bartolini B, Piselli P, Mazzarelli A, Copetti M, Binda E, Perri F, Gruber CEM, Nicastri E, Marchioni L, Ippolito G, Capobianchi MR, Di Caro A and Pazienza V.
Published in: International Journal of Environmental Research and Public Health, 2021, ISSN 0000-0000
Publisher: Ivan Gentile, Annamaria Colao and Prisco Piscitelli
DOI: 10.3390/ijerph18042174

Effective screening strategy against SARS-CoV-2 on self-collected saliva samples in primary school setting: A pilot project

Author(s): Effective screening strategy against SARS-CoV-2 on self-collected saliva samples in primary school setting: A pilot project
Published in: The journal of infection, 2021, ISSN 0000-0000
Publisher: The journal of infection
DOI: 10.1016/j.jinf.2021.05.013

SARS-CoV-2 Early Screening at the Point of Entry: Travelers From Bangladesh to Italy–July 2020.

Author(s): Rueca M, Di Caro A, Gruber CEM, Messina F, Giombini E, Valli MB, Lalle E, Lanini S, Vairo F, Capobianchi MR, and Bartolini B.
Published in: Frontiers in Genetics, 2021, ISSN 0000-0000
Publisher: Sheikh A. Rahman, Emory University, United States
DOI: 10.3389/fgene.2021.625607

Intellectual Property Rights

Patent (1)

AN APPARATUS AND ASSOCIATED METHODS FOR THERMAL CYCLING

Application/Publication number: 20 22050686
Date: 2022-03-18
Applicant(s): B G RESEARCH LTD