T-cell-induced immune programming and degeneration of the neuronal tissue during chronic autoimmunity

Project Information

T-Neuron

Grant agreement ID: 101021345

DOI

10.3030/101021345

EC signature date 10 July 2021

Start date 1 September 2021

End date 31 August 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 374 863,00

EU contribution

€ 2 374 863,00

Coordinated by

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions

Author(s): Matthias Münchhalfen, Richard Görg, Michael Haberl, Jens Löber, Jakob Willenbrink, Laura Schwarzt, Charlotte Höltermann, Christian Ickes, Leonard Hammermann, Jan Kus, Björn Chapuy, Andrea Ballabio, Sybille D. Reichardt, Alexander Flügel, Niklas Engels, Jürgen Wienands
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51166-3

Mitochondrial calcium uniporter complex controls T-cell-mediated immune responses

Author(s): Magdalena Shumanska, Dmitri Lodygin, Christine S Gibhardt, Christian Ickes, Ioana Stejerean-Todoran, Lena C M Krause, Kira Pahl, Lianne J H C Jacobs, Andrea Paluschkiwitz, Shuya Liu, Angela Boshnakovska, Niels Voigt, Tobias J Legler, Martin Haubrock, Miso Mitkovski, Gereon Poschmann, Peter Rehling, Sven Dennerlein, Jan Riemer, Alexander Flügel, Ivan Bogeski
Published in: EMBO Reports, Issue 26, 2025, Page(s) 407-442, ISSN 1469-3178
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44319-024-00313-4

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

Author(s): Hosang L, Löhndorf A, Dohle W, Rosche A, Marry S, Diercks B-P, Müller-Kirschbaum LC, Flügel LT, Potter BVL, Odoardi F, Guse AH, Flügel A
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Issue Volume 1870 Issue 6, 2023, Page(s) 119485, ISSN 0167-4889
Publisher: Elsevier BV
DOI: 10.1016/j.bbamcr.2023.119485

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease.

Author(s): Schäffner E, Bosch-Queralt M, Edgar JM, Lehning M, Strauß J, Fleischer N, Kungl T, Wieghofer P, Berghoff SA, Reinert T, Krueger M, Morawski M, Möbius W, Barrantes-Freer A, Stieler J, Sun T, Saher G, Schwab MH, Wrede C, Frosch M, Prinz M, Reich DS, Flügel A, Stadelmann C, Fledrich R, Nave K-A, Stassart RM
Published in: Nature Neuroscience, Issue Volume 26, Issue 7, 2023, Page(s) 1218-1228, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-023-01366-9

The lung microbiome regulates brain autoimmunity.

Author(s): Hosang L, Cugota Canals R, van der Flier FJ, Hollensteiner J, Daniel R, Flügel A*, Odoardi F* *equal contribution
Published in: Nature, Issue Volume 25, Issue 7, 2022, 2022, Page(s) 138-144, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04427-4