Project description
Thinking about formal thought disorder in psychiatry
Understanding thought processes could shed new light on psychiatric disorders. Up to now, researchers have focused on the contents of maladaptive thoughts. The EU-funded DynaT project will think about the process by which thoughts come to mind. Formal thought disorder (FTD), for instance, is a disruption in the form and organisation of one’s thoughts. Considered a hallmark feature of psychosis, FTD remains one of the least understood symptoms in psychosis, with no treatments. To dissociate impairments in thought dynamics from impairments in the communication or expression of thought, DynaT will use state-of-the-art computational psychiatry methods. With the use of mathematical modelling and machine learning algorithms, the project will tap thought dynamics from the participants’ brain activity in real time.
Objective
Psychiatric disorders are often characterized by maladaptive thought patterns. Whereas most research focuses on the distinct contents of maladaptive thoughts, abnormalities in the process by which thoughts come to mind are often overlooked. One exception is formal thought disorder (FTD), defined as a disruption in the form and organization of thought (e.g. loose associations). FTD is considered a hallmark feature of psychosis. Furthermore, recent evidence suggests that FTDs are found in other psychiatric disorders. Despite progress in the research of FTD in the recent decades, FTD remains one of the least understood symptoms in psychosis (all the more so in other disorders), with no established treatments. One key issue is that most FTD research focuses on language and communication impairments (e.g. disorganized speech), and not on actual thoughts. The overall aim of 'Dynamics of thought and thought disorders' (DynaT) is to dissociate impairments in thought dynamics from impairments in the communication or expression of thought, without relying on introspective self-report. To deal with the challenge of measuring covert thought, DynaT will use state-of-the-art computational psychiatry methods. First, DynaT will use mathematical modelling to gain insight into the covert thoughts preceding participants' observed responses. Second, DynaT wil use machine-learning algorithms to tap thought dynamics from the participant's brain activity in real-time. DynaT will isolate and characterise several component processes of FTD in schizophrenia and across the wider, transdiagnostic psychopathological spectrum, including: a) semantic disorganization; b) impaired inhibitory control of thoughts; c) inflexible reliance on predominant, local associations. As the first investigation to dissociate (objectively measured) covert thoughts from overt speech, DynaT has the potential to significantly advance the conceptualization and understanding of FTDs across disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine psychiatry
- medical and health sciences health sciences speech-language pathology
- natural sciences computer and information sciences artificial intelligence machine learning
- natural sciences mathematics applied mathematics mathematical model
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
WC1E 6BT LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.