Project description
A holistic view on cancer immune evasion
Understanding anti-tumour immunity is central for the design of effective immunotherapy strategies. However, the clonal nature of tumours leads to heterogeneity in treatment response and even drug resistance. Scientists of the EU-funded TxImmuneOrganoids project propose to address this challenge through the development of appropriate patient-derived models. They will establish organoids from non-small cell lung cancer (NSCLC) patients and study their interaction with autologous or allogeneic T cells. Results will provide a holistic and mechanistic overview of immune surveillance and evasion in NSCLC. Moreover, identification of putative molecular determinants may open opportunities for novel anti-cancer interventions.
Fields of science
Programme(s)
Funding Scheme
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
Coordinator
NW1 1AT London
United Kingdom
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