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Nano bio-responsive systems designed to avoid staphylococcal colonization of implant interfaces

Project description

Advanced joint implants with unique antimicrobial properties

Hip and knee arthroplasty are common surgical treatments in orthopaedic surgery for restoring the function of an injured or diseased joint. These procedures rely heavily on replacement prostheses, which however may accumulate bacteria, leading to periprosthetic joint infection. To address this serious medical issue, the EU-funded NanoBioRS project proposes to develop a smart molecular coating that combines tissue growth factors with antimicrobials. Moreover, it will contain enzymes that prevent biofilm formation on joint prostheses as well as antimicrobial resistance spread. The NanoBioRS solution could be used to coat various implantable materials, thereby addressing the health threat of staphylococcus-resistant bacteria.

Objective

Antimicrobial resistance (AMR) is responsible for 25,000 deaths per year in the EU and costs EUR 1.5 billion annually. Methicillin-sensitive Staphylococcus aureus (MSSA), Methicillin-resistant S. aureus (MRSA) and S. epidermidis remain a serious problem in the treatment of periprosthetic joint infection (PJI).
After surgery, bacteria may attach to the surface of prosthetic joints to form biofilms. The fate of an available surface can be conceptualized as a race between tissue cell integration and bacterial adhesion to that same surface. If the race is won by tissue, then the surface is occupied and defended and is thus less available for bacterial colonization.
The integration of the synthetic routes for smart molecular coatings doped with anti-staphylococcal agents that promote tissue growth, their biological responses and biointerface interactions into functional nano bio-responsive systems (NanoBioRS) able to avoid PJI is an unexplored opportunity for innovation.
In order to tackle PJI and to contribute to avoid the development and spread of antimicrobial resistance, NanoBioRS aims to engineer smart coatings equipped with three frontlines: (i) Increased adhesiveness of their interface to favour tissue cell integration. (ii) Smart responses to eradicate MSSA, MRSA and S. epidermidis using antimicrobials that are not prompt to resistance development. (iii) Means of avoiding biofilm and horizontal gene transfer (HGT) of AMR.
Thiol-modified polymers, surface-tethered stimuli-responsive polymer brushes and antimicrobial/antifouling agents will render coatings with eukaryotic cell adhesive, smart bacterial contact-kill and anti-biofilm properties, respectively. Endonucleases will be used to avoid biofilm and HGT of AMR. Implant surfaces will be modified with NanoBioRS. Nanoscale characterization will allow for the understanding of biointerface interactions taking place during eukaryotic cell colonization and bacterial invasion of implants.

Coordinator

UNIVERSITAET INNSBRUCK
Net EU contribution
€ 279 250,56
Address
INNRAIN 52
6020 Innsbruck
Austria

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Region
Westösterreich Tirol Innsbruck
Activity type
Higher or Secondary Education Establishments
Links
Total cost
€ 279 250,56